Pharm Block 2 (Thyroid Gland)
Home > Flashcards > Print Preview
The flashcards below were created by user
on FreezingBlue Flashcards. What would you like to do?
What are the Two Thyroid hormones?
Which has the longer half life? Stronger acting?
Thyroxine (T4) and Triiodothyronine (T3)
- T4 has a longer half life
- T3 4X more potent
What is Graves disease?
What is Hashimoto's
- Hyperthyroidism- It is an autoimmune disease--> excess in Thyroid hormones
What are the Clinical Features of :
- - Heat intolerance
- - Tachycardia
- - Tremors
- - increased basal metabolic rate
- - Cold intolerance
- - Bradycardia
- - Decreased Deep tendon reflex
- - increased cholesterol
How is Thyroxine metabolized?
What does it?
difference between inner and outer ring?
It is Deiodinated
- Inner ring --> inactive reverse T3
- Outer ring--> active T3
What inhibits 5'-monodeiodinase?
What does this do?
- beta blockers
- High does propylthiouracil
- prevents the conversion of T4 to T3
From the Blood, what is the mechanism of Thyroid hormones?
- -T4 dissociate from thyroxine binding globulin in plasma before entry into cells.
- -In the cells, T4 is enzymatically deiodinated to T3 which enters nucleus and attaches to specific receptors which promotes protein synthesis.-->
What converts I- to Thyroglobulin?
What inhibits it?
- - Peroxidase and H2O2
- - Iodides and Thioamides
What enzyme prevents the release of T3/T4 from the Thyroid Follicle?
Iodides inhibit the Proteolysis of the Conjugated Thyroglobin
What drugs do the following:
Inhibition of hormone synthesis?
Blockade of hormone release?
T4 to T3 inhibitors?
What are anion inhibitors?
- -Propylthiouracil and Methimazole.
-They prevent the uptake of Iodine into the thyroid follicle. They are TOXIC
Name the ANTI-thyroid Thioamides
What do they do?
Which is more potent?
How soon till it works?
Which do you use in pregnancy?
Other uses ?
- they inhibit Peroxidase
- Methimazole is more potent so it can be used once a day.
- Works in about 3 weeks. this is because the Thyroid Follicle has alot of Thyroid hormones stored.
- - Propylthiouracil, is safe for use during pregnancy.
- - Can be used in Prep for Surgery (decrease size of tumor)
What are some adverse effects of Thioamides?
- -maculopapular rash, arthralgia and vasculitis.
- -Agranulocytosis – reversible.
What is Potassium Iodide?
What does it do?
What are some uses?
Is it slow acting?
is it used long term?
It is an Anti-thyroid Drug
. an Inorganic iodide
- It Blocks the organification and release through inhibition of Proteolysis
- It decrease the size and vascularity – used before surgery preoperatively. and in thyroid storm treatment.-It is Fast Acting
- -It is not for long term as gland ‘escapes’ from its effect.
What are some adverse effects of
-Chronic use in pregnancy-->fetal goiter.
-Iodine induced thyrotoxicosis (Jod Basedow’s phenomenon) at low doses.
-salivary gland inflammation and acne.
What is Radioactive Iodine?
What is its mechanism?
What is a 100% side effect?
When is this treatment contraindicated?
-It is a I-131 isotope
is used in treatment of thyrotoxicosis and cancer while others are used in diagnosis.
- - Given to patients--> Thyroid cells take it up--> in about 1-3 months -->emission of beta rays which destroys the thyroid gland. (IRREVERSIBLE)- Patients become Hypothyroid (treat with replacement theropy).
_Contraindicated in Pregnant Women
What would you like to do?
Home > Flashcards > Print Preview