Card Set Information
what is DD if has only motor signs and no sensory?
MND - distinguish as it also has LMN signs with MS doesnt
other name for MND is amyotrophic lateral sclerosis
what is DD for brainstem syndromes
: downward displacements of cerebellar tonsils through foramen magnum
MRI and CSF can distinguish
what is it called when there is a monophasic illness characterised by widespread multifocal demyelination in isolation? how can tell difference between MS?
acute disseminated encephalomyelitis
of after infection
: post infectious encephalomyelitis
Multiple ares of demyelination separated in space BUT NOT IN TIME
how are acute relapses of MS treated?
if severe enough to limit function eg due to limb weakness or visual failure then treat with high dose iv or oral methylprednisolone 500mg-1g
for 3-5 days
must exclude UTI before starting steroids
which 2 drugs are used to reduce the rate of progression and relapses of MS? and SE
: SE flu like symptoms, CI in pregnancy
: fewer SE but worse ISR (injection site reactions)
which newer drug is twice as effective as glatiramer? what type of drug? SE?
monoclonal antibody natalizumab against integrin adhesion molecule
: PML - progressive multifocal leucoencephalopathy
: mitoxantrone - anthracycline derivative but SE cardiotoxicity, acute leukaemia
which drugs are used to control spasticity, flexor spasms? what is SE?
: sedative at high dose
dantrolene (use in NMS too due to rigidity)
: weakness, drowsy
inject botox into affected muscles
cannabinoids - sativex
PHYSIO! - stretch exercises
which drugs are used to control cerebellar tremor?
isoniazid with pyridoxine
which drugs are used to control fatigue?
: anti narcolepsy drug
which drugs are used to control bladder disturbances?
: oxybutinin or tolterodine or solifenacin
relax detrusor muscle
intermittent self catheterisation if post micturition bladder RV > 100ml
which drugs are used to control depression?
which drugs are used to control erectile impotence?
which drugs are used to control pain, paroxysmal symptoms inc seizures?
which drugs are used to control constipation?
: eg fybogel - ispaghula husk
: eg docusate
movicol - polyethylene glycol