Bio 210 Final

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Author:
romichaj
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50136
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Bio 210 Final
Updated:
2010-11-17 02:08:18
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bio exam Proteins
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Proteins
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  1. Only a small portion of genomic DNA is used to code for proteins.
    true
  2. The phenotype of cells differ because of differences in gene expression.
    True
  3. Cells exist in a state of equilibrium where rates of forward reactions are equal rates of the reverse reaction.
    False
  4. Subtle aspects of structural information encoded in genes include specifying sequences of amino acids involved in protein-protein interactions and post-translational modifications.
    True
  5. Vaccine development for the HIV virus has been slow because of the variability in surface proteins like gp120.
    True
  6. . The enzyme that makes cAMP from ATP is

    a. adenylate cyclase

    b. cAMP-dependent protein kinase

    c. cAMP phosphodiesterase

    d. any phosphatase

    e. cAMP-dependent phospholipase
    adenylate cyclase
  7. 7. GTP - binding proteins

    a. can bind either GDP or GTP

    b. have GTPase activity

    c. act as binary (on/off) switches

    d. help amplify a hormone's signal
    e. all the above
    e
  8. . Protein kinases can recognize

    a. ser or thr residues within a certain primary sequence.

    b. lysine residues in the
    C-terminus.

    c. special antibody preparations.

    d. hydrophobic patches on the surface of
    proteins.

    e. phosphodiester bonds in protein-DNA
    complexes.
    A
  9. Reactions
    with a positive ∆G are said to be

    a. spontaneous

    b. favored

    c. non-spontaneous

    d. unlikely

    e. unwelcome
    C
  10. Cells are metastable; spontaneous reactions

    a. proceed at a slow rate because high activation energies
    require enzymes.

    b. proceed at a fast rate
    because they are favored.

    c. proceed readily because of
    the availability of ATP.

    d. only proceed to the left.

    e. proceed at fast rates because of highly
    negative ∆G values.
    A
  11. .
    Catalysts work by

    a. increasing the energy level
    of the transition state.

    b. donating functional groups
    that become part of the product of the reaction.

    c. decreasing the
    activation energy.

    d. make the ∆G values more favorable.

    e. effectively shifting the equilibrium to the
    right by mass action.
    C
  12. Ubiquitin is

    a. a highly conserved protein found
    in most all eukaryotic cells

    b. a yeast protein engineered for cell use

    c. is secreted
    so that it can attach to antigens and aid in antibody recognition

    d. is highly
    mutated so that it can carry out many diverse functions

    e. is localized
    to the nucleus and can activate RNA polymerase
    A
  13. Activation of PKA (cAMP-dependent protein kinase A) results in

    a. activation of
    gluconeogenesis

    b.
    phosphorylation and inactivation of glycogen synthase

    c.
    phosphorylation and activation of phosphorylase kinase

    d. phosphorylation and inactivation of glycogen
    synthase

    e. both b and d
    are correct
    C
  14. Protein kinases

    a. are enzymes
    that cleave phosphates from protein substrates

    b. are enzymes
    that activate G-proteins

    c. are enzymes that transfer the
    gamma-phosphate from ATP to a protein substrate

    d. are used
    during sugar metabolism when mitochondria make ATP

    e. modify the 5'
    ends of nucleotides.
    C
  15. A protein with ubiquitin bound

    a. has 1 N -terminus
    and 2 C-termini

    b. has 2
    N-termini and 2 C-termini

    c.
    has 2 N-termini and 1 C-terminus

    d. has a mutated
    arginine

    e. is no big
    deal
    C
  16. Trimeric G-proteins function to couple activated receptors to the production of second messengers like cAMP
    True
  17. DNA sequence information can be used to develop polypeptide antigens.
    True
  18. Binding partners of protein X can be identified in immunoprecipitates with antiX antibodies.
    True
  19. Protein degradation is an ATP-dependent process.
    True
  20. ATP hydrolysis is coupled to non-spontaneous reactions to give them an overall negative ∆G.
    True
  21. Only pure proteins can act as antigens.
    false
  22. Monoclonal antibodies are produced by B cell:myeloma hybridomas.
    true
  23. If an enzyme's activity is sensitive to salt and pH, which amino acids might be involved in binding at the active site?

    a.
    gly and ala

    b. trp and phe

    c.
    glu, lys and his

    d. ser, gln, and val

    e.
    impossible to say
    C
  24. Phosphofructokinase, an important rate-controlling enzyme in glycolysis, is activated allosterically by

    a.
    AMP and ADP

    b. ATP

    c. GTP

    d. citrate

    e. calcium
    A
  25. . B cells respond to ___________ and make___________.

    a. light; ATP

    b. insulin; sugar

    c. cAMP; adrenalin

    d.
    T cells; antigens

    e. antigens; immunoglobulins
    E

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