Discuss the different types of thrombocytopenia that are AEs of heparin
Type I: HAT - Heparin-associated Thrombocytopenia - direct interaction betw heparin and platelets - can cause bleeding - non-immune. Tx is d/c heparin.
Type II: HIT - Heparin-induced Thrombocytopenia - serious allergic rxn - immune-mediated - heparin intx with platelets results in activation of coagulation cascade causing clots - DVT, PE, MI, stroke, etc. Tx is d/c heparin. If clots have formed, use a direct thrombin inhibitor or fondaparinux. Warfarin may be used when platelets > 150,000. UH and LMWH cross reactive in HIT.