Micro Quiz 12

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Author:
bamerb07
ID:
50249
Filename:
Micro Quiz 12
Updated:
2010-11-17 16:18:02
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Svinth Micro Quiz
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Micro Svinth quiz 12
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  1. Evading or Surviving Phagocytosis
    • Avoid contact
    • Kill the phagocyte
    • Survive phagocytosis
    • Escape endocytic vesicle
  2. Avoid Contact
    • Capsule
    • M protein
    • Opa
  3. Kill the Phagocyte
    • Gm+ lysins (pop a hole in something else)
    • Streptolysin O, S
    • Leukocidin (enzyme that targets WBCs)
    • Cause leakage of lysosomal enzymes with cell

    • Gm- exotoxins
    • Adenylate cyclases decrease phagocytic activity
  4. Survive Inside Phagocytes
    • Mycolic acid (obligate intracellular parasites)
    • The liquid on them keeps them from being digested
  5. Escape the Phagosome
    Phospholipase
  6. How Pathogens Damage Host Cells
    • Use Host Nutrients
    • Causing Direct Damage @ site of invasion
    • Toxin Production
    • Inducing Hypersensitivity Reactions
  7. Using Host Nutrients
    • Many pathogens need Fe (cofactor for a lot of enzymes)
    • Fe tied up in lactoferrin, transferrin, ferritin, Hb (Take in iron but they give it away)
    • Receptors for Fe-protein complexes
    • Siderophores (Iron scavenger-grabs the iron and its gone. It keeps it)
    • Siderophore receptor
  8. Direct Damage
    • Proliferation of pathogen in host
    • Host cell ruptures
    • Buildup of wastes
    • Host cell dies
  9. Production of Toxins
    • Toxigenicity: ability of microbe to produce toxin
    • Toxemia: presence of toxin in blood
    • Gm+/Gm- both produce soluble toxins during exponential growth
  10. Toxins
    • Proteins: Exotoxin (secreted/external to bacteria)
    • Lipids: Endotoxin (part of the bacteria)
  11. Exotoxins
    • Secreted proteins
    • Similar to enzymes:
    • Proteins
    • Denatured by pH, temp, chemicals
    • Specific
    • High catalytic activity/turnover
  12. 3 Categories of Exotoxins
    • A/B proteins
    • Membrane-Disrupting
    • Superantigens (force the cell to mount a huge response)
  13. A/B Proteins
    • These have two parts:
    • A: activity
    • B: binding (on outside)
  14. Diseases of A/B Protein Toxins
    • Anthrax
    • Botulism
    • Cholera
    • Diptheria
    • Tetanus
  15. Membrane Disruption
    • Lyse plasma membrane
    • Form channels (pore) Remove contents
    • Disrupt phospholipids
  16. Membrane Disruptors
    • Channel formers
    • Leukocidin
    • Hemolysins
    • Streptolysin

    • Phospholipid disruption
    • Clostridium
  17. Superantigens
    • Antigens that provoke a huge immune response
    • Stimulate T cell proliferation (secretes the cytokines)
    • Release cytokines
    • Fever
    • Nausea
    • Diarrhea
    • Vomiting
    • Shock (loss of blood pressure)
    • Death
  18. Toxins and enzymes produced by S. aureus
    • Enterotoxin
    • Superantigen
    • Beta Hemolysin
    • Leukocidin
    • Coagulase
    • Hyaluronidase
    • Exfoliatin
    • fibrinolysin
  19. LPS
    • Gm-
    • Lipid A
    • Released during replication or death

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