PHARMA BASIC PRINCIPLES

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Anonymous
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50818
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PHARMA BASIC PRINCIPLES
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2010-11-20 21:52:49
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PHARMACOLOGY
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BASIC PRINCIPLES
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  1. 1) Which of the following is NOT part of the etymology of the word pharmacology?
    A) Study
    B) Herb
    C) Poison
    D) Drug
    E) Medicine
    B) Herb
    (this multiple choice question has been scrambled)
  2. 2.1) Which of the following describes an agonist?
    a) Any substance that brings about a change in biologic function through its
    chemical action
    b) A specific regulatory molecule in the biologic system where a drug interacts
    c) A drug that binds to a receptor and stimulates cellular activity
    d) A drug that binds to a receptor and inhibits or opposes cellular activity
    e) A drug directed at parasites infecting the patient
    C. A drug that binds to a receptor and stimulates cellular activity
  3. 2.2) Xenobiotics are considered:
    a) Endogenous
    b) ExogenOUS
    B. ExogenOUS
  4. 2.3) Which of the following would be a toxin (poison of biological origin)?
    a) Pb
    b) As
    c) Hg
    d) Atropine
    D. Atropine
  5. 2.4) The vast majority of drugs have molecular weights (MW) between 100 and 1,000. Large drugs, such as alteplase (t-PA), must be administered:
    a) Into the compartment where they have their effect
    b) Orally so they do not absorb too quickly
    c) Rectally to prevent irritation to the stomach lining and vessels
    d) Via the intraosseous (IO) route
    e) Titrated with buffering agents to prevents cell lysis
    A. Into the compartment where they have their effect
  6. 2.5) Which of the following occurs with drugs that are extremely small, such as Lithium?
    a) Receptor mediated endocytosis
    b) Minor drug movement within the body
    c) Vasodilation when injected intravenously (IV)
    d) Specific receptor binding
    e) Nonspecific binding
    E. Nonspecific binding
  7. 2.6) Drugs fit receptors using the lock and key model. Covalent bonds are the ____ and the ____ specific.
    a) Strongest; Most
    b) Strongest; Least
    c) Weakest; Most
    d) Weakest; Least
    B. Strongest; Least
  8. 2.7) Warfarin (Coumadin) is given as a racemic mixture with the S enantiomer being four times more active than the R enantiomer. If the mixture of Warfarin given is 50% S and 50% R, what is the potency compared with a 100% R enantiomer solution?
    a) 4 * R + 1 * S = 1
    b) 4 * R + 1 * S = 1.5
    c) 4 * R + 1 * S = 2
    d) 4 * R + 1 * S = 2.5
    e) 4 * R + 1 * S = 4
    D. 4 * R + 1 * S = 2.5
  9. 2.8) What determines the degree of movement of a drug between body compartments?
    a) Partition constant
    b) Degree of ionization
    c) pH
    d) Size
    e) All of the above
    E. All of the above
  10. 3.1) Which of the following is NOT a protein target for drug binding?
    a) Side of action (transport)
    b) Enzymes
    c) Carrier molecules
    d) Receptors
    e) Ion channels
    A. Side of action (transport)
  11. 3.2) Which of the following is an example of a drug acting directly through receptors?
    a) Protamine binds stoichiometrically to heparin anticoagulants
    b) Adrenergic beta blockers for thyroid hormone-induced tachycardia
    c) Epinephrine for increasing heart rate and blood pressure
    d) Cancer chemotherapeutic agents
    e) Mannitol for subarachnoid hemmorhage
    C. pinephrine for increasing heart rate and blood pressure
  12. 4.1) What is added with drug subclassification, such as an antitubercular drug versus an antibacterial drug?
    a) Cost
    b) Size
    c) Ionization
    d) Precision
    e) Speed
    D. Precision
  13. 4.2) What type of drug is propranolol (Inderal)?
    a) Anticonvulsive
    b) Antihypertensive
    c) Antinauseant
    d) Antihistamine
    e) Antipyretic
    B. Antihypertensive
  14. 5.1) Which of the following is considered the brand name?
    a) Propranolol
    b) Inderal
    c) Adrenergic ß-blocker
    d) “off label” use
    e) Blocks ß-receptors in heart myocardium
    B. Inderal
  15. 5.2) Which of the following is considered the class?
    a) Propranolol
    b) Inderal
    c) Adrenergic ß-blocker
    d) “off label” use
    e) Blocks ß-receptors in heart myocardium
    C. Adrenergic ß-blocker
  16. 5.3) Which of the following cases would be contraindicated for propranolol (Inderal)?
    a) Hypertension
    b) Essential tremor
    c) Angina
    d) Tachycardia
    e) Asthma
    E. Asthma
  17. 5.4) Which of the following adverse effects (side-effects) is NOT commonly seen with cholinergic antagonists?
    a) Blurred vision
    b) Confusion
    c) Miosis
    d) Constipation
    e) Urinary retention
    C. Miosis
  18. 6.1) The drug chloramphenicol (Chloromycetin) is risky for which of the following?
    a) Neonates
    b) Geriatric patients
    c) Adult males
    d) Obese patients
    e) Congestive heart failure patients
    A. Neonates
  19. 6.2) How does the glomerular filtration rate (GFR) change after the age of 40?
    a) Increase 1% each year
    b) Increases 2% each year
    c) Decreases 1% each year
    d) Decreases 2% each year
    e) Does not depend on age
    C. Decreases 1% each year
  20. 6.3) A decrease in renal and liver function, as seen in the elderly, would prolong drug half-life, ____ plasma protein binding, and ____ volume of distribution.
    a) Increase; Increase
    b) Decrease; Decrease
    c) Increase; Decrease
    d) Decrease; Increase
    B. Decrease; Decrease
  21. 6.4) When prescribing isoniazid (Rimifon), pharmacogenetics must be considered as >90% of Asians and certain other groups are ____ acetylators, and thus have a ____ blood concentration of a given dose and a decreased risk of toxicity.
    a) Slow; Increased
    b) Slow; Decreased
    c) Fast; Increased
    d) Fast; Decrease
    D. Fast; Decrease
  22. 6.5) Which of the following are the two modifying factors that contribute to why women have higher blood peak concentrations of alcohol than men when consuming equivalent amounts?
    a) Lower blood volume & increased hormones
    b) Lower fat content & more gastric alcohol dehydrogenase (ADH)
    c) Higher fat content & more gastric alcohol dehydrogenase (ADH)
    d) Lower fat content & less gastric alcohol dehydrogenase (ADH)
    e) Higher fat content & less gastric alcohol dehydrogenase (ADH)
    E. Higher fat content & less gastric alcohol dehydrogenase (ADH)

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