JL a 26 yr old female, visits the physician in early spring with complaints of sneezing, itching eyes, and stuffy nose. The physician advises JL to take an OTC antihistamine with decongestant, fexofenadine D (similar to allegra D). Two weeks after starting the medication, she reports good relief of her symptoms.
1. How are receptors involved in JL's symptoms?
2. What signaling pathways are activated?
3. What pharmacodynamic mechanisms does fexofenadine D utilize to alleviate her symptoms?
4. What type of drug (antagonsit, agonist, etc.) is fexofenadine?
5. What type of drug is represented by the "D" and what type of pharmacological agent is it?
- 1. histamine receptors-excess production of the agonist histamine caused JL's symptoms which stimulated this family of receptors; adrenergic receptors--the "D" in JL's fexofenadine D acted via these receptors
- 2. overstimulation of receptors or pathways--excess of histamine in JL's case
- 3. binds to adrenergic receptors?
- 4. competitive antagonist?
- 5. adrenergic receptors--the "D" in JL's fexofenadine D acted via these receptors