PBD 4 PD

Card Set Information

Author:
swynocker
ID:
51040
Filename:
PBD 4 PD
Updated:
2010-11-21 23:48:25
Tags:
PBD PD
Folders:

Description:
PBD 4 PD
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user swynocker on FreezingBlue Flashcards. What would you like to do?


  1. Late onset occurs at
    60 years of age, 95% (sporadic)
  2. Late stage motor symptoms
    • Tremor (pill rolling)
    • ridgidity
    • bradykinesia
    • posture instab.
  3. Three cardinal signs of PD
    • bradykinesia
    • rigidity
    • resting tremor
  4. Imaging techniques
    TCS, MRI, PET, SPECT, Diffuse MRI

    PET and SPECT are best
  5. T/F Dementia or AD symptoms may appear in some PD patients
    True
  6. Non-motor symptoms occur ______ in PD
    early
  7. Postmortem diagnosis is due to loss of neuromelanin-rich dopaminergic neurons in the _____ ____.
    Substantia nigra
  8. Lewy bodies account for _%_ of clinical diagnosis.
    85%
  9. Lewy bodies contain
    • neurofilament proteins
    • lipids
    • ubiquitin
    • alpha-synuclein
  10. Direct pathway is mediated by __ receptor and indirect is mediated by __ receptor.
    D1, D2
  11. Direct path goes from striatum to the _______ _____. Indirect goes from Striatum through ___ and ______.
    • Globus pallidus internal
    • GPe
    • Nigro-striatal
  12. In PD ______ of DA in striatum leads to (more/less) stimulation on striatal GABA-releasing neurons innervating the ____ _____ ______.
    • Depletion
    • Less
    • Globus pallidus internal
  13. In PD _______ of dopamine in striatum leads to (more/less) inhibition via D2 on the STN glutamate releasing neurons. Therefore, the stimulatory action on GABA releasing in GPi is ________.
    • Depletion
    • Increased
  14. Non motor symptoms of PD
    • Sensory
    • sleep- insomnia, vivid dreams
    • psychiatric- depression, apathy, hallucinate
    • GI- constipated
    • Bladder disturbance
    • fatigue
  15. Movement pathway includes the ______ __ pathway
    Nigrostriatal DA pathway
  16. T/F Protein folding is the main cause of formation of lewy bodies and cell damage
    true
  17. Park1-a-synuclein
    • 3 mis sense mutations
    • unfolded protein
    • a-synuclein found in lewy bodies
  18. Park2 (parkin)
    • account for 50% autosomal recessive PD
    • overexpression toxic to DA neurons
  19. DJ-1 Park7
    • Loss of function
    • DJ-1 knock out mice increased sens. to MPTP induced loss of nigral DA neurons
  20. Pink1 Park 6
    • Mitochondrial dysfunction
    • increase sensitivity to DA toxins
  21. Park 8 LRRK2
    • Leucine rich repeast Kinase 2
    • synaptic vissicle recycling
  22. T/F lower incidicene of PD in caffeine drinkers and smokers
    True
  23. Cell death mechanisms in PD
    • Oxidative stress
    • Excitatory toxicity
    • Reduced trophic support
    • Inflammation in brain
    • Mitochondrial dysfunction
  24. Treatment for PD
    • Levo-Dopa
    • Pallodotomy, thalamotomy, DB stim.

What would you like to do?

Home > Flashcards > Print Preview