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what are some gram positive rods that are in CMN group? and what are the distictive cell wall components?
- the unusual cell wall component are
- myolic acid
- cord factor
what is the difference in the myolic acid of the 3 bacteria in CMN group?
- mycobacteria had the longest chanin and strongly acid fast
- nocardia had the intermediate chain and weakly acid fast
- corynebacteria has the shortest chain and not acid fast
what are the two categories that corynebacterium falls under?
pathogenic ( C.diphtheriae) non.pathogenic ( opportunistic and part of common microflora C.jeikeium )
what are some characteristics of Corynebacteria
- gram positive
- non.spore forming
- metamprphic (methylene blue stain)
- not acid fast
- facultative anaerobe
- enhanced by Co2
- catalase +
- grows waxy
- ferments carbs to lactic acid
what are some pathogenic factors associated with corynebacterium
- cord factor
- exotoxin ( result in phage conversion)
- two component Toxin
- potent inhibitor of protein synthesis
- ADP ribosylation
what are some toxin's associated with C.diphtherea
- Type 3 toxin
- A/b subunit toxin
- .A subunit inhibits interacellular target
- .b subunit mediate binding to target cell and internallization
** toxin action in C.diphtherea inactivate elongation factor 2 preventing protein sysnethis by ribsome
what are some factors involved in pathogenisis
- it is localized infection to tonsils and orpharynx and spread to larynx and trachea
- sypm 2.5 days
- obstruction of airways
** common microflora
what media does C.diphterease reduce and what color colonies are produced?
it reduces CTA to produce black colonies
what are some diagnostic ways ?
- ELK test
- Toxin test ( vivo test is animal ) vitro test (PCR)
how does C.diphtrea spread ? what is the host? and where is it usually localized to ?
- it is transmitted by aerosal droplet, and also carried by asymptomatic carriers
- and in healthy is localized to oropharynx.
what types of immunizations are present?
passive and active(toxoid)
what are some ways to treat C.diphtereae?
- penecilin G(erythromycin)
- active passive immunization
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