Phase II: glucuronic acid (#1) and sulfates attached (forms water-soluble metabolite); often inactive and ready for excretion. Biliary excreted drugs may become deconjugated in intestines with reabsorption, some in active form.
Inihibitors of P450:
Inducers of P450:
1) cruciform vegetables
4) cigarrette smoke
5) phenobarbital (barbituates)
What does P450 do to aromatic hydrocarbons?
P450 system transforms aromatic hydrocarbons into carcinogens
What is the most important organ for eliminating most drugs?
Kidney- most important organ for eliminating most drugs (glomerular filtration and tubular secretion)
Polar drugs (ionized)-
more water soluble and more likely to be elimintated in unaltered form
Nonpolar drugs (nonionized)-
more fat soluble and more likely to be metabolized before excretion
1) caused by uric acid buildup; end product of purine metabolism
2) Colchicine- anti-inflammatory; binds tubulin and inhibits migration