Card Set Information
How does endothelin-1 work?
Increases intracellular Ca2+ in smooth muscle tissue of blood vessels -> contraction -> vasoconstriction.
How does Bosentan work?
Competitive non-selective antagonist of endothelin-1 at ET-A and ET-B receptors
Decreased pulmonary vascular resistance.
Name two ET-A blockers?
: low liver toxicity, high potency.
Where are prostacyclins synthesized, where and how do they act?
Synthesized in endothelial cells
Act on smooth muscle cells through G-protein, increase protein kinases -> vasodilation.
What do prostacyclin analogs have in their name?
What is the ending of PDE 5 selective inhibitors, how do they work?
inhibit degradation of cGMP -> vasodilation.
What is Inomax, how are systemic effects prevented?
Inhaled nitric oxide
Rapid binding to hemoglobin.
What is Dornase Alfa, what is it used for?
Recombinant human DNase (rhDNase)
Enzyme selectively cleaves DNA
Inhalable, used in CF, reduces viscosity in lungs
Improved clearance of secretions.
What is the MOA of N-Acetyl-Cysteine (NAC)?
Rate limiting step in glutathione (GSH) synthesis - provides precursor so increases GSH (antioxidant).
What is NAC used for?
Acetominophen overdose, decreases amount of toxic NAPQI.
What three factors does the viscosity of mucus depend on?
Concentration of mucoproteins
Presence of di-sulfide bonds
Mucolytics usually contain one of which two compounds?
What is the MOA of ambroxol?
Stimulates synthesis and release of surfactant by type 2 pneumocytes
Also has local anaesthetic effect.
What is almitrine, how does it work?
Agonist at peripheral chemoreceptor
Increase PaO2 and decrease PaCO2.
What do surfactant analogs have in their name?