glucocorticoids (prednisone, prednisoline, hydrocortisone, budesonide)
- - used to treat IBD
- - MOA: activate GC receptors to act on promoters of target genes and regulate their transcription
- - antiinflammatory and immunosuppressive
- - used for attacks of mod-severe IBD or non-responders to 5-ASA.
- - rectal administration is prefered if disease in rectum/colon b/c of lower systemic absorption
- - not useful to maintain remission, most patients lose response over time.