MCB 62 Opiates 2 10/28

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Author:
elainewest
ID:
52711
Filename:
MCB 62 Opiates 2 10/28
Updated:
2010-12-01 18:15:27
Tags:
mcb
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  1. What do opioids do in the brain?
    agonist @ opioid proteins
  2. Endogenous Neurotransmitters
    • Endorphins
    • - from "endogenous morphine"
    • -neuropeptides
    • *long chains of amino acids
    • *larger than glutamate and GABA
  3. Opioid Addiction/ Treatment
    • -detoxification and negotiation withdrawl
    • -dealing with cravings
    • -ongoing psychological and behavioral programs
  4. Psychological/ Behavioral Programs for Opioid Addiction
    • 12 step
    • Narcotics Anonymous
    • individual and group psychotherapy
    • opioid replacement therapies
  5. Opioid Replacement Therapies
    methadone/buprenorphine (semi-synthetic opioid, agonist, not as potent, easier to taper off)
  6. Abuse/ Addiction Potential
    • pharmacology
    • quantity used/dose
    • route of admin
    • psychological context
    • social/environmental complex
  7. James Olds-1954
    • learning in rats
    • stimulated different parts of the brain with electricity to see if they learned better
    • rat pressed bar to recieve stimulation
    • one part of the brain it would press over and over again and ignore everything else and even cross a painful grid
  8. Reward Reinforcement Pathway
    • frontal cortex --> nucleus accumbens (N.A.) --> ventral tegmental
    • dopamine is the NT
    • compulsion to do it again and again
    • feels frustrating
  9. Drugs and the Reward Pathway
    • Drugs having abuse potential facilitate increased dopamine activity in the reward pathway
    • This results in changes in synaptic stress
  10. Behavioral Addictions
    • gambling
    • video game playing
    • shopping
    • sex
    • pornography
    • eating
  11. Treating Behavioral Addictions
    • work w/ a crisis treatment center
    • breaking the cycle
    • consolidating abstinence
    • creating a new lifestyle with social support networks, recreational activities, and coping skills

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