Hydrochlorothiazide [HydroDIRUIL, HCTZ]
- Thiazide Diuretic
- blocks reabsabsorption in early segment of DCT, where 10% water is reabsorbed
- use: Hypertension, Edema, CHF
- ae: all the same as Furosemide, but to a lesser degree
- intrxn: Digoxin (toxicity), NSAIDs (blunt fx), Antihypertensives (change fx), Lithium (↑ to toxic levels), Potassium-Sparing Diuretics (compensate K+ loss)
- Most Widely Used, more mild effects.
- Dependent on Renal Fxn, cannot use if Renal Impairment.