PColFlashcards.txt

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klcorley
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PColFlashcards.txt
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PCol Drugs Semester 1
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  1. Dobutamine
    Beta-1 Adrenergic Receptor AGONIST
  2. Acebutolol
    • Beta-1 Adrenergic Receptor ANTAGONIST
    • Sectral
  3. Atenolol
    • Beta-1 Adrenergic Receptor ANTAGONIST
    • Tenormin
  4. Betaxolol
    • Beta-1 Receptor Adrenergic ANTAGONIST
    • Kerlone
  5. Bisprolol
    • Beta-1 Receptor Adrenergic ANTAGONIST
    • Zebeta
  6. Metoprolol
    • Beta-1 Receptor Adrenergic ANTAGONIST
    • Toprol XL, Lopressor
  7. Esmolol
    • Beta-1 Receptor Adrenergic ANTAGONIST
    • Brevibloc
  8. Albuterol
    • Beta-2 Adrenergic Receptor AGONIST
    • ProAir, Proventil
  9. Bitolterol
    • Beta-2 Adrenergic Receptor AGONIST
    • Tornalate
  10. Formoterol
    • Beta-2 Adrenergic Receptor AGONIST
    • Foradil
  11. Isoetharine
    Beta-2 Adrenergic Receptor AGONIST
  12. Levabuterol
    • Beta-2 Adrenergic Receptor AGONIST
    • Xopenex
  13. Metaproterenol
    • Beta-2 Adrenergic Receptor AGONIST
    • Alupent
  14. Pirbuterol
    • Beta-2 Adrenergic Receptor AGONIST
    • Maxair
  15. Salmeterol
    • Beta-2 Adrenergic Receptor AGONIST
    • Serevent
  16. Terbutaline
    Beta-2 Adrenergic Receptor AGONIST
  17. Ritodrine
    Beta-2 Adrenergic Receptor AGONIST
  18. Isoproterenol
    • Non-Selective Beta-Adrenergic Agonist
    • both Beta-1 and Beta-2
    • Isuprel
  19. Propranolol
    • Non-Selective Beta-ANTAGONIST
    • Inderal
  20. Nadolol
    • Non-Selective Beta-ANTAGONIST
    • Corgard
  21. Pindolol
    Non-Selective Beta-ANTAGONIST
  22. Timolol
    Non-Selective Beta-ANTAGONIST
  23. Sotalol
    • Non-Selective Beta-ANTAGONIST
    • Betapace
  24. Levobunalol
    Non-Selective Beta-ANTAGONIST
  25. Midodrine
    Selective Alpha-1 Receptor AGONIST
  26. Phenylephrine
    Selective Alpha-1 Receptor AGONIST
  27. Pseudoephedrine
    • Selective Alpha-1 Receptor AGONIST
    • Sudafed
  28. Oxymetazoline
    • Selective Alpha-1 Receptor AGONIST
    • Afrin
  29. Prazosin
    • Selective Alpha-1 Receptor ANTAGONIST
    • Minipress
  30. Terazosin
    • Selective Alpha-1 Receptor ANTAGONIST
    • Hytrin
  31. Doxazosin
    • Selective Alpha-1 Receptor ANTAGONIST
    • Cardura
  32. Alfuzosin
    • Selective Alpha-1 Receptor ANTAGONIST
    • Uroxatral
  33. Tamsulosin
    • Selective Alpha-1 Receptor ANTAGONIST
    • Flomax (Alpha-1A)
  34. Yohimbine
    • Selective Alpha-2 Receptor ANTAGONIST
    • works in the CNS
  35. Clonidine
    • Selective Alpha-2 Receptor AGONIST
    • Catapres
  36. Methyldopa
    Selective Alpha-2 Receptor AGONIST
  37. Guanabenz
    Selective Alpha-2 Receptor AGONIST
  38. Guanfacine
    • Selective Alpha-2 Receptor AGONIST
    • Tenex,Intuniv
  39. Brimonidine
    • Selective Alpha-2 Receptor AGONIST
    • Alphagan
  40. Dexmedetomine
    • Selective Alpha-2 Receptor AGONIST
    • Precedex
  41. Apraclonidine
    • Selective Alpha-2 Receptor AGONIST
    • Iopidine
  42. Labetalol
    • Beta-1, Beta-2, and Alpha-1 Receptor ANTAGONIST
    • Trandate
  43. Carvedilol
    • Beta-1, Beta-2, and Alpha-1 Receptor ANTAGONIST
    • Coreg
  44. Phentolamine
    • Non-Selective Alpha ANTAGONIST
    • OraVerse
  45. Phenoxybenzamide
    Non-Selective Alpha ANTAGONIST
  46. General Effects of Alpha-1 Receptor Activation??
    Overall Effects??
    • General: vasoconstriction, capillary constriction, decreased urination, mydriasis
    • Overall: Increase TPR, and get reflex decrease in HR
  47. General Effects of Alpha-2 Receptor Activaiton?
    Overall Effects?
    • General: decrease firing of sympathetic neurons, decrease release of NE at the nerve ending, decrease aqueous humor production
    • Overall: decrease TPR, decrease BP, and decrease HR
  48. General Effects of Beta-2 Receptor Activation??
    Overall Effects?
    • General: bronchodilation, uterine relaxation, vasodilation, gylcogenolysis, gluconeogenesis, increase in the production of aqueous humor
    • Overall: relaxation, decreased TPR, and again reflex increase HR
  49. General Effects of Beta-1 Receptor Activation??
    Overall Effects?
    • General: SA node increased firing, AV node increased nodal conduction, increased contractility, increased stroke volume, increased automaticity, increased renin secretion
    • Overall: Direct increase in HR
  50. Clidinium
    Muscarinic Receptor ANTAGONIST
  51. Propantheline
    Muscarinic Receptor ANTAGONIST
  52. Mepenzolate
    Muscarinic Receptor ANTAGONIST
  53. Cyclopentolate
    • Muscarinic Receptor ANTAGONIST
    • Cyclogyl
  54. Tropicamide
    • Muscarinic Receptor ANTAGONIST
    • Mydriacyl
  55. Glycopyrrolate
    • Muscarinic Receptor ANTAGONIST
    • Robinul
  56. Tolterodine
    • Muscarinic Receptor ANTAGONIST
    • Detrol
  57. Oxybutinin
    • Muscarinic Receptor ANTAGONIST
    • Ditropan
  58. Flavoxate
    • Muscarinic Receptor ANTAGONIST
    • Urispas
  59. Dicyclomine
    • Muscarinic Receptor ANTAGONIST
    • Bentyl
  60. Hyoscyamine
    • Muscarinic Receptor ANTAGONIST
    • Levsin
  61. Scopolamine
    • Muscarinic Receptor ANTAGONIST
    • Transderm-Scope
  62. Belladonna
    Muscarinic Receptor ANTAGONIST
  63. Ipratropium
    • Muscarinic Receptor ANTAGONIST
    • Atrovent
  64. Tiotropium
    • Muscarinic Receptor ANTAGONIST
    • Spiriva
  65. Atropine
    • Muscarinic Receptor ANTAGONIST
    • AtroPen
  66. Darifenacin
    • Muscarinic Receptor ANTAGONIST
    • Enablex
  67. Solifenacin
    • Muscarinic Receptor ANTAGONIST
    • Vesicare
  68. Trospium
    • Muscarinic Receptor ANTAGONIST
    • Sanctura
  69. Bethanechol
    • Muscarinic Receptor AGONIST
    • Urecholine
  70. Carbachol
    Muscarinic Receptor AGONIST
  71. Cevimeline
    • Muscarinic Receptor AGONIST
    • Evoxac
  72. Pilocarpine
    • Muscarinic Receptor AGONIST
    • Salagen
  73. Physostigmine
    Cholinesterase Inhibitor
  74. Pyridostigmine
    • Cholinesterase Inhibitor
    • Mestinon
  75. Ambenonium
    • Cholinesterase Inhibitor
    • Mytelase
  76. Malathion
    • Cholinesterase Inhibitor
    • Ovide
  77. Neostigmine
    • Cholinesterase Inhibitor
    • Prostigmin
  78. Edrophonium
    • Cholinesterase Inhibitor
    • Enlon
  79. Echothiophate
    • Cholinesterase Inhibitor
    • Phospholine Iodide
  80. Botulinum Toxin
    • Indirect Sympatholytic
    • Botox
  81. Gaunethidine
    Indirect Sympatholytic
  82. Guanadrel
    Indirect Sympatholytic
  83. Reserpine
    Indirect Sympatholytic
  84. Metyrosine
    • Indirect Sympatholytic
    • Demser
  85. Cisatracurium
    Muscle Nicotinic Receptor Antagonist
  86. Rocuronium
    Muscle Nicotinic Receptor Antagonists
  87. Mivacurium
    Muscle Nicotinic Receptor Antagonist
  88. Rapacuronium
    Muscle Nicotinic Receptor Antagonist
  89. Pipecuronium
    Muscle Nicotinic Receptor Antagonist
  90. Pancuronium
    Muscle Nicotinic Receptor Antagonist
  91. Vecuronium
    Muscle Nicotinic Receptor Antagonist
  92. Doxacurium
    Muscle Nicotinic Receptor Antagonist
  93. Atracurium
    Muscle Nicotinic Receptor Antagonist
  94. Nicotine
    Central Acting Nicotinic Receptor AGONIST
  95. Varenicline
    • Centrally Acting Nicotinic Receptor PARTIAL AGONIST
    • Chantix
  96. Succinylcholine
    Muscle Nicotinic Receptor AGONIST (the only 1)
  97. General Effects of Cholinesterase Inhibitors??
    Overall?
    • General: increase bronchoconstriction, increase GI motility, increase urination, miosis, increase glandular secretions
    • Overall: enhance the effects of the PNS
  98. General Effects of Muscarinic Receptor Activation??
    Overall?
    • General: increase bronchoconstriction, increase GI motility, increase urination, miosis, increase glandular secretions
    • Overall: enhance the effects of the PNS
  99. General Effects of Muscle Nicotinic Receptor Antagonists??
    Overall?
    • General: inhibit Ach at the neuromuscular end plate
    • Overall: muscle paralysis
  100. General Effects of Indirect Sympatholytics??
    Overall?
    • General: inhibit post-ganglionic functioning of the SNS by blocking NE
    • Overall: antihypertensives decrease both HR and vessel resistance
  101. General Effects of Nicotinic Receptor Ligands??
    Overall?
    • General: stimulation causes muscle contraction, and in the brain some may be linked to reward centers
    • Overall: Muscle contraction
  102. Acetazolamide
    • Diuretic: Carbonic Anhydrase Inhibitor
    • Diamox
  103. Methazolamide
    • Diuretic: Carbonic Anhydrase Inhibitor
    • Neptazane
  104. Darzolamide
    • Diuretic: Carbonic Anhydrase Inhibitor
    • Trusopt
  105. Furosemide
    • Loop Diuretics "High Ceiling"
    • Lasix
  106. Bumetanide
    • Loop Diuretics "High Ceiling"
    • Bumex
  107. Torsemide
    • Loop Diuretics "High Ceiling"
    • Demadex
  108. Ethacrynic Acid
    • Loop Diuretics "High Ceiling"
    • Edecrin
  109. Hydrochlorothiazide
    • Thiazide Diuretic
    • Hydrodiuril
  110. Chlorothiazide
    • Thiazide Diuretic
    • Diuril
  111. Indapamide
    • Thiazide Diuretic
    • Lozol
  112. Metolazone
    • Thiazide Diuretic
    • Zoroxolyn
  113. Amiloride
    • Na Channel Inhibitors/ K-sparing Diuretics
    • Midamor
  114. Triamterene
    • Na Channel Inhibitors/ K-sparing Diuretics
    • Dyrenium
  115. Spirinolactone
    • Aldosterone Antagonists/ K-sparing Diuretics
    • Aldactone
  116. Eplerenone
    • Aldosterone Antagonists/ K-sparing Diuretics
    • Inspra
  117. Mannitol, Urea, Glycerin
    Osmotic Diuretics
  118. Nifedipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • Procardia
  119. Nislodipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • Sular
  120. Nicardipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • Cardene
  121. Nitrendipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • Baypress
  122. Felodipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • Plendil
  123. Amlodipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • Norvasc
  124. Nimodipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • Nimotp
  125. Isradipine
    • Calcium Channel Blockers; 1,4 Dihydropyridines
    • DynaCirc
  126. Verapamil
    • Calcium Channel Blockers; Arylalkyl Amines
    • Isoptin, Calan
  127. Bepridil
    • Calcium Channel Blockers; Arylalkyl Amines
    • Vascor
  128. Diltiazem
    • Calcium Channel Blocker; Benzothiazepine
    • Cardiazem
  129. Ephedrine
    Indirect Acting Sympathomimetics
  130. General Effects of Indirect Acting Sympathomimetics??
    Overall?
    • General: mimic the actions of the sympathetic nervous system
    • Overall: direct agonist at alpha-1, beta-1, and beta-2 SO good decongestant (vasoconstriction), increases HR, and good bronchodilators
  131. Ma Huang
    • Indirect Acting Sympathomimetic
    • potent stimulant of beta-1 receptors
  132. Dopamine
    • Catecholamine: D1 (Gs) receptors on smooth muscle
    • If DA given exogenously get vasodilation mainly in the renal artery increasing perfusion to the kidney also increasing GFR;
    • some affinity for beta-1 so may increase HR;
    • some affinity for alpha-1 so some vasoconstriction (NOT desired)
    • TX: oliguria and bradycardia
  133. Fenoldapam
    • D1 AGONIST
    • TX: hypertensive crisis w/ or w/o oliguria
    • Corlopam
  134. Epinephrine
    • ULTIMATE ADRENERGIC AGONIST
    • Alpha-1, Alpha-2, Beta-1, Beta-2
  135. Vasopressin (ADH)
    • AGONIST V2(collecting duct) and V1(vascular and gastric sm. muscle) Receptors
    • V2 = increase # aquaporins so increase H2O reabsorption
    • V1 = vasoconstriction, reduce GI bleeds
  136. Desmopressin (DDAVP)
    • AGONIST V2(collecting duct)
    • TX: Central Diabetes Insipidus (inadequate secretion of ADH)
    • Nocturnal Enuresis (bedwetting)
  137. General Effects of ACE Inhibitors?
    • Treat Hypertension: via decrease in SVR, decrease in mean diastolic and systolic pressures, also left ventricular systolic dysfunction (mild asymptomatic to HF), and renal protection DM and non-DM to slow progression of renal disease
    • This increases compliance of large arteries, no increase in sympathetic tone or cardiac output with treatment, also no BP changes with postural changes or exercise
  138. Benazapril
    • ACE Inhibitor
    • Lotensin
  139. Captopril
    • ACE Inhibitor
    • Capoten
  140. Enalapril; Enalaprilat
    • ACE Inhibitor
    • Vasotec
  141. Fosinopril
    • ACE Inhibitor
    • Monopril
  142. Lisinopril
    • ACE Inhibitor
    • Prinivil
  143. Moexipril
    • ACE Inhibitor
    • Univasc
  144. Quinapril
    • ACE Inhibitor
    • Accupril
  145. Perinodopril
    • ACE Inhibitor
    • Aceon
  146. Ramipril
    • ACE Inhibitor
    • Altace
  147. Trandolapril
    • ACE Inhibitor
    • Mavik
  148. General Effects of ARBs??
    • TX: hypertension, renal protection in DM and non-DM to slow progression of renal disease, overt diabetic nephropathy, HF when intolerant to ACEIs
    • Contracts vascular smooth muscle, release of adrenal catecholamines thus enhances noradrenergic neurotransmission, increase sympathetic tone, secretion of ADH and aldosterone
  149. Candesartan
    • ARB: Insurmountable
    • Atacand
  150. Olmesartan
    • ARB: Insurmountable
    • Benicar
  151. Irbesartan
    • ARB: Insurmountable
    • Avapro
  152. Telmisartan
    • ARB: Insurmountable
    • Micardis
  153. Losartan
    • ARB: Surmountable
    • Cozaar
  154. Valsartan
    • ARB: Surmountable
    • Diovan
  155. Eposartan
    • ARB: Surmountable
    • Tevetan
  156. General Effects of Direct Renin Inhibitors??
    • TX: hypertension reducing BP comparable to ACEIs and ARBs
    • Prevents generation of Ang I from angiotensinogen, competitive inhibitor of renin enzymatic activity
  157. Aliskiren
    • Direct Renin Inhibitors
    • Tekturna
  158. General Effects of Organic Nitrates??
    • TX: angina
    • Reduces preload and cardiac work load via venous dilation and increases supply of O2 via arterial dilation
  159. Nitroglycerin
    • Organic Nitrate
    • Nitrostat
  160. Isosorbide Dinitrate
    • Organic Nitrate
    • Isordil
  161. Isosorbide-5-Mononitrate
    • Organic Nitrate
    • Imdur
  162. Nitroprusside
    • Direct Vasodilator: Nitro-vasodilator
    • NitroPress
  163. Hydralazine
    • Direct Vasodilator
    • Apresoline
  164. Hydralazine/Isosorbide Dinitrate
    • Direct Vasodilator
    • BiDil
  165. Minoxidil
    Direct Vasodilator
  166. Diazoxide
    • Direct Vasodilator
    • Proglycem
  167. Nesiritide
    • Direct Vasodilator
    • Natrecor
  168. General Effects Endothelin Antagonists??
    • TX: Pulmonary hypertension
    • Causes decrease in vasoconstriction and proliferation of smooth muscle
  169. Bosentan
    • Endothelin Antagonist
    • Selective for Type A and Type B Receptor
    • Tracleer
  170. Ambrisentan
    • Endothelin Antagonist
    • Selective for Type A receptor
  171. General Effects of Prostacyclin Agonists??
    • TX: pulmonary hypertension
    • Cause vasodilation and reduce smooth muscle proliferation
  172. Epoprostenol
    • Prostacyclin Agonist
    • Flolan
  173. Treprostinil
    • Prostacyclin Agonist
    • Remodulin
  174. Iloprost
    • Prostacyclin Agonist
    • Ventavis
  175. General Effects of PDE-5 Inhibitors??
    • TX: Pulmonary Hypertension
    • If inhibit these enzymes we increase levels of cyclic nucleotides and thus get more vasodilation
    • Not as effective as prostacyclin agonists or endothelin antagonists
  176. Sildenafil
    • PDE-5 Inhibitor
    • Revatio, Viagra
  177. Tadalafil
    • PDE-5 Inhibitor
    • Cialis
  178. Vardenafil
    • PDE-5 Inhibitor
    • Levitra
  179. Papverine
    PDE-5 Inhibitor
  180. General Effect of PGE-1 Analogue??
    • TX: Erectile Dysfunction
    • Prostaglandin E-1 is a vasodilator when their receptors are activated
  181. Alprostadil
    • PGE-1 Analogue
    • Caverject, Muse
  182. General Effects of HMG-CoA Reductase Inhibitors??
    • Decrease TG by decreasing hepatic synthesis of VLDL and increasing hepatic uptake of IDL and VLDL remnants.
    • Increase HDL by stimulating pre-beta-HDL synthesis, stimulate CE hydrolysis and HDL maturation
  183. Atorvastatin
    • HMG-CoA Reductase Inhibitor
    • Lipitor
  184. Rosuvastatin
    • HMG-CoA Reductase Inhibitor
    • Crestor
  185. Pravastatin
    • HMG-CoA Reductase Inhibitor
    • Pravachol
  186. Simvastatin
    • HMG-CoA Reductase Inhibitor
    • Zocor
  187. Fluvastatin
    • HMG-CoA Reductase Inhibitor
    • Lescol
  188. Lovastatin
    • HMG-CoA Reductase Inhibitor
    • Mevacor
  189. General Effects of Bile Acid Sequestrants??
    • TX: Decrease Serum LDL levels in dyslipidemia
    • Positively charged resins bind to negative charges on bile acids and prevent their absorption (resins are NOT absorbed)
  190. Cholestyramine
    • Bile Acid Sequestrants
    • Questran
  191. Colestipol
    • Bile Acid Sequestrants
    • Colestid
  192. Colesevalem
    • Bile Acid Sequestrants
    • Welchol
  193. General Effects of Fibrates??
    • TX: hypertriglyceridemia and mixed hyperlipidemia, and metabolic syndrome
    • Reduce TG and increase circulating HDL
  194. Gemfibrozil
    • Fibrate
    • Lopid
  195. Fenofibrate
    • Fibrates
    • Tricor
  196. Niacin
    • TX: hypertriglyceridemia, dyslipidemia in combo with other drugs
    • Niaspan
    • Decrease VLDL, Decrease LDL, Increase HDL half life and decrease TG
  197. General Effects of Cholesterol Absorption Inhibitors??
    • TX: dyslipidemia
    • Decrease cholesterol absorption from small intestine, increase hepatic LDL receptor expression, increase gene expression of HMGCo-A reductase
  198. Ezetimibe
    • Cholesterol Absorption Inhibitor
    • Zetia
  199. Milrinone
    • PDE-3 Inhibitor
    • Ionotropic
    • Primacor
  200. Inamrinone
    • PDE-3 Inhibitor
    • Ionotropic
  201. Digoxin
    • Na/K Pump Inhibitor
    • Ionotropic (vagal effect so may be used as anti-arrhythmic)
    • Lanoxin
  202. Digibind
    • Digoxin Toxicity Antidote
    • Slow Tissue Effects
    • Digoxin Immune Fab
  203. Adenosine
    • Anti-arrhythmic
    • Reduces activity of SLOW conduction tissue
    • Adenocard;Adenoscan
  204. Quinidine
    • Anti-arrhythmic: Class 1 A
    • Na Channel Blocker (Fast Tissue)
  205. Procainamide
    • Anti-arrhythmic: Class 1 A
    • Na Channel Blocker (Fast Tissue)
  206. Disopyramide
    • Anti-arrhythmic: Class 1 A
    • Na Channel Blocker (Fast Tissue)
    • Norpace; Norpace CR
  207. Lidocaine
    • Anti-arrhythmic: Class 1B
    • Na Channel Blocker (Fast Tissue)
    • Xylocaine
  208. Mexilitene
    • Anti-arrhythmic: Class 1 B
    • Na Channel Blocker (Fast Tissue)
  209. Flecainide
    • Anti-arrhythmic: Class 1 C
    • Na Channel Blocker (Fast Tissue)
    • Tambocor
  210. Propafenone
    • Anti-arrhythmic: Class 1 C
    • Na Channel Blocker (Fast Tissue)
    • Rythmol;Rythmol SR
  211. Ibutilide
    • Anti-arrhythmic: Class 3
    • K Channel Blocker
    • Corvert
  212. Sotalol
    • Anti-arrhythmic: Class 3
    • K Channel Blocker
    • Betapace
  213. Dofetilide
    • Anti-arrhythmic: Class 3
    • K Channel Blocker
    • Tikosyn
  214. Amiodarone
    • Anti-arrhythmic: Class 3
    • K Channel Blocker
    • Cordarone;Pacerone
  215. Dronadarone
    • Anti-arrhythmic: Class 3
    • K Channel Blocker
    • Multaq
  216. Class 2 Vaughn Williams
    • Anti-arrhythmics: Beta-Blockers
    • Slow Tissue Effects
    • Acebutolol (Sectral)
    • Atenolol (Tenormin)
    • Betaxolol (Kerlone)
    • Bisoprolol (Zebeta)
    • Carvedilol (Coreg)
    • Esmolol (Brevibloc)
    • Labetalol (Trandate)
    • Levobunalol (Betagan)
    • Nadolol (Corgard)
    • Nebivolol (Bystolic)
    • Pindolol (Visken)
    • Propranolol (Inderal)
    • Metoprolol (Toprol;Lopressor)
    • Sotalol (Betapace)
  217. Class 4 Vaughn Williams
    • Anti-arrhythmic: Ca Channel Blockers
    • Slow Tissue Effects
    • Verapamil
    • Blocks L-type Ca Channels to reduce Ca entry
    • Decrease late pacemaker current
    • Decrease SA firing, AV conduction
    • Increase action potential duration
    • Increase refractory period of AV node
  218. General Effects of K Channel Blockers?
    • Block the delayed rectifier current
    • Prolong the action potential
    • Increase the refractory period of Fast Tissue
    • Do NOT decrease conduction
    • No inhibition of Na Channels
    • Increase Ca entry which may lead to Torsades de Pointes in 10% of patients
  219. General Effects of Na Channel Blockers?
    • Higher affinity for open and inactivated Na Channels
    • Lower affinity for resting state so will dissociate from channels in resting state
    • Use Dependent block properties wherein those channels used more often will develop more block
  220. General Effects of PDE-3 Inhibitors
    • Raise levels of cAMP
    • Increase in heart muscle contraction
    • *increased levels of cyclic nucleotides may lead to arrhythmias
  221. Aspirin
    • Anti-platelet Drug
    • Inhibits IRREVERSIBLY cycloxygenase
  222. Ticlopidine
    • Anti-platelet Drug
    • P2Y12 Receptor Antagonist (Block ADP from binding)
    • Ticlid
  223. Clopidogrel
    • Anti-platelet Drug
    • P2Y12 Receptor Antagonist (Block ADP from binding)
    • Plavix
  224. Prasugrel
    • Anti-platelet Drug
    • P2Y12 Receptor Antagonist (Block ADP from binding)
    • Effient
  225. Abciximab
    • Anti-platelet Drug
    • GP2B/3A Antagonist (stops fibrinogen cross-linkage)
    • IRREVERSIBLY binds
    • Reopro
  226. Tirofiban
    • Anti-platelet Drug
    • GP2B/3A Antagonist (stops fibrinogen cross-linkage)
    • REVERSIBLY binds
    • Aggrastat
  227. Eptifibatide
    • Anti-platelet Drug
    • GP2B/3A Antagonist (stops fibrinogen cross-linkage)
    • REVERSIBLY binds
    • Integrilin
  228. Dipyridamole
    • Anti-platelet Drug
    • Increases cAMP
    • PDE-3 Inhibitor
    • Reduces up-take of adenosine by RBC
  229. Cilostazol
    • Anti-platelet Drug
    • PDE-3 Inhibitor
  230. Pentoxyfiline
    • Anti-platelet Drug (sorta...)
    • Changes the shape of RBC to allow for easier movement in thrombotic vessels
  231. Anagrelide
    • Anti-platelet Drug
    • Inhibits maturation of megakaryocytes into platelets i.e. inhibits platelet formation
  232. Heparin
    Anti-Coagulant
  233. Lovenox (Enoxaparin)
    • Anti-Coagulant
    • LMW Heparins
  234. Fragmin
    • Anti-Coagulant
    • LMW Heparins
  235. Innohep
    • Anti-Coagulant
    • LMW Heparins
  236. Fondaparinox
    • Anti-Coagulant
    • Factor Xa Inhibitor
    • Arixtra
  237. Desirudin
    • Anti-Coagulant
    • Thrombin (Factor IIa) Inhibitor
  238. Lepirudin
    • Anti-Coagulant
    • Thrombin (Factor IIa) Inhibitor
  239. Bivalirudin
    • Anti-Coagulant
    • Thrombin (Factor IIa) Inhibitor
  240. Argatroban
    • Anti-Coagulant
    • Thrombin (Factor IIa) Inhibitor
  241. Dabigatran
    • Anti-Coagulant
    • Thrombin (Factor IIa) Inhibitor
    • Pradaxa
  242. Warfarin
    • Anti-Coagulant
    • Reduces synthesis of Factors II, VII, IX, X by blocking Vitamin K Reductase
    • Coumadin
  243. Xigris
    • Anti-Coagulant
    • Recombinant Activated Protein C
    • TX: Sepsis
  244. Streptokinase
    Thrombolytic/Fibrinolytic Drug
  245. Urokinase
    Thrombolytic/Fibrinolytic Drug
  246. Activase
    • Thrombolytic/Fibrinolytic Drugs:
    • Tissue Plasminogen Activator
  247. Retavase
    Thrombolytic/Fibrinolytic Drugs:Tissue Plasminogen Activator
  248. TNKase
    Thrombolytic/Fibrinolytic Drugs:Tissue Plasminogen Activator
  249. Aspirin
    COX Inhibitor
  250. Diflunisal
    • COX Inhibitor: Non-acetylated salicylates
    • Dolobid
  251. Salsalate
    • COX Inhibitor: Non-acetylated salicylates
    • Disalcid
  252. Choline Magnesium Trisalicylate
    • COX Inhibitor: Non-acetylated salicylates
    • Trilisate
  253. Diclofenac
    • COX Inhibitor: NSAIDs
    • Voltaren, Cataflam
  254. Etodolac
    • COX Inhibitor: NSAIDs
    • Lodine
  255. Fenoprofen
    • COX Inhibitor: NSAIDs
    • Nalfon
  256. Flurbiprofen
    • COX Inhibitor: NSAIDs
    • Ansaid
  257. Ibuprofen
    • COX Inhibitor: NSAIDs
    • Motrin
  258. Indomethacin
    • COX Inhibitor: NSAIDs
    • Indocin
  259. Ketoprofen
    • COX Inhibitor: NSAIDs
    • Orudis
  260. Ketorolac
    • COX Inhibitor: NSAIDs
    • Toradol
  261. Meloxicam
    • COX Inhibitor: NSAIDs
    • Mobic
  262. Mefenamic Acid
    • COX Inhibitor: NSAIDs
    • Ponstel
  263. Nabumetone
    • COX Inhibitor: NSAIDs
    • Relafen
  264. Naproxen
    • COX Inhibitor: NSAIDs
    • Naprosyn
  265. Oxaprozin
    • COX Inhibitor: NSAIDs
    • Daypro
  266. Piroxicam
    • COX Inhibitor: NSAIDs
    • Feldene
  267. Sulindac
    • COX Inhibitor: NSAIDs
    • Clinoril
  268. Tolmetin
    • COX Inhibitor: NSAIDs
    • Tolectin
  269. General Effects of COX inhibitors??
    Oerall?
    • General: decrease production of TXA2, PGI-2 and PGE-2
    • Overall: decrease pain, decrease hightened temperatures (aka fever) and decrease inflammation (only high dose or selective COX-2 inhibitors)
  270. Celecoxib
    • Selective COX-2 Inhibitor
    • Celebrex
  271. Acetaminophen
    • COX inhibitor
    • Tylenol
  272. Zafirlukast
    • Leukotriene Receptor Antagonist
    • Accolate
  273. Montelukast
    • Leukotriene Receptor Antagonist
    • Singulair
  274. Zileuton
    • 5-lipoxygenase Inhibitor
    • Zyflo CR
  275. Colchicine
    Anti-Gout
  276. Allopurinol
    • Anti-Gout: Xantine Oxidase Inhibitor
    • Zyloprim, Aloprim
  277. Feboxustat
    Anti-Gout: Xanthine Oxidase Inhibitor
  278. Probenecid
    Anti-Gout: Uricosuric
  279. Sulfinpyrazone
    Anti-Gout: Uricosuric

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