MED-Naloxone

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Author:
amerelman
ID:
54977
Filename:
MED-Naloxone
Updated:
2010-12-11 13:28:00
Tags:
MED Naloxone
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Description:
MED-Naloxone
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  1. Functional Class
    Narcotic antagonist
  2. Mechanism of Action
    Competes for, and dispaces, narcotic molecules from opiate receptors in the brain
  3. Indications
    • Opiate overdose
    • Coma of unknown origin
  4. Contraindications
    Hypersensitivity
  5. Precautions
    Use caution on narcotic physically-dependent patients as naloxone can cause abrupt reversal of narcotic effects
  6. Side Effects
    • N/V
    • HTN
    • Ventricular arrhythmias
    • Tachycardia
    • Hyperventilation
    • Tremors
  7. Interactions
    May cause narcotic withdrawal in the narcotic-dependent patient so administer only enough to reverse respiratory depression
  8. Dosage and Route
    • Adult: 0.4-2 mg IVP/IM/SQ/ET q 2-3 mins max 10 mg
    • (double dose if administering ET)

    • Pedi: 0.1 mg/kg IVP/IO/IM/ET/SQ
    • (double dose if ET)
    • q 2-3 mins max 10 mg
  9. Pharmacokinetics
    • Onset: 2-10 mins IM/ET, <2 mins IV
    • Duration: 20-120 mins
    • Half-life: 60-90 mins

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