Drugs Group 1

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oteff
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58295
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Drugs Group 1
Updated:
2011-01-05 19:40:56
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Drugs Group 1
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  1. DILTIAZEM (CARDIZEM)
    Class:
    Calcium channel blocker
  2. DILTIAZEM (CARDIZEM)
    Mechanism of Action
    Diltiazem interferes with the entry influx of calcium intocardiac and vascular smooth muscle. In addition it slowsthe rate of the SA node and conduction velocity throughthe AV node. Diltiazem’s ability to relax coronaryarteries, as well as its negative inotropic and negativechronotropic qualities makes it a useful antianginal. It isalso used as an antihypertensive. However in theprehospital setting, we use it primarily as anantidysrhythmic so its ability to slow the conductionthrough the AV node is most pertinent.
  3. DILTIAZEM (CARDIZEM)
    Indications:
    To control rapid ventricular rates associated with atrial fibrillationand atrial flutter, and SVT refractory to adenosine
  4. DILTIAZEM (CARDIZEM)
    Contraindications:
    Should not be administered to any patient with severehypotension or cardiogenic shock, ventricular tachycardia(wide-complex tachycardia), atrial flutter or atrial fibrillation inpatients with WPW (may precipitate ventricular fibrillation)
  5. DILTIAZEM (CARDIZEM)
    Interactions:
    Should not be administered to patients receiving intravenous β-blockers because of an increased risk of CHF, bradycardia, andasystole
  6. DILTIAZEM (CARDIZEM)
    Dosage:
    0.25 mg/kg over 2 minRepeat 0.35 mg/kg if no response in 15 minMaximum single dose: 20-25 mg.Maintenance infusion of 5–15 mg/hr
  7. MAGNESIUM SULFATE
    Class:
    Electrolyte, Antidysrhythmic
  8. MAGNESIUM SULFATE
    Mechanism of Action:
    Increases the magnesium levels, correcting for possiblehypomagnesemia, which is associated with cardiacdysrhythmias. Magnesium interferes with neuromusculartransmission, reducing muscle contractions in seizuresand bronchoconstriction
  9. MAGNESIUM SULFATE
    Indications:
    Torsades de Pointes, v-fib / v-tach in patients felt to behypomagnesemic, refractory v-fib, preeclampsia and eclampsia,refractory bronchoconstriction, TCA OD (if QRS is wide)
  10. MAGNESIUM SULFATE
    Contraindications:
    Shock, heart block
  11. MAGNESIUM SULFATE
    Precautions:
    Calcium chloride is antidote if respiratory depression ensues,caution in renal failure patients
  12. MAGNESIUM SULFATE
    Interactions:
    May block effect of digitalis
  13. MAGNESIUM SULFATE
    Dosage: Cardiac Arrest
    1-2 g IV push
  14. MAGNESIUM SULFATE
    Dosage: Cardiac w/pulse
    1-2 g IV, over 5-60 min
  15. MAGNESIUM SULFATE
    Dosage: Preeclampsia and eclampsia
    2-4 g IV, over 5-60 min
  16. MAGNESIUM SULFATE
    Dosage: Bronchoconstriction
    2 g IV, over 5-60 min
  17. METOPROLOL
    Class:
    Beta-blocker (β1 predominance)
  18. METOPROLOL
    Mechanism of Action:
    Selectively antagonizes beta-1 adrenergic receptors,causing a reduction in heart rate, systolic bloodpressure, and cardiac output. It is thought to beprotective of the heart and is used to reduce potentialcomplications in selected patients who have suffered anAMI. Metoprolol has proved effective in reducing theincidence of ventricular fibrillation and chest pain inthese patients, thus reducing overall patient mortality inthe post-MI period
  19. METOPROLOL
    Indications:
    Suspected or definite hemodynamically stable AMI
  20. METOPROLOL
    Contraindications:
    Heart rate less than 45 bpm, systolic BP less than 100,moderate to severe CHF, first-degree heart block with a PRinterval greater than 0.24 sec, second-degree heart block(Type I or II), third-degree heart block, any patient with earlyor late signs of shock
  21. METOPROLOL
    Side Effects:
    Bradycardia, hypotension, dyspnea, and wheezing
  22. METOPROLOL
    Dosage:
    5 mg slow IV, q 5 min x 3 total doses if vitals remain stable

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