Pharm II (Chemo Id)

Card Set Information

Author:
Anonymous
ID:
58648
Filename:
Pharm II (Chemo Id)
Updated:
2011-01-08 12:51:12
Tags:
Pharm II Chemo Id
Folders:

Description:
Pharm II (Chemo Id)
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Anonymous on FreezingBlue Flashcards. What would you like to do?


  1. What are the major classes of hormonal Theropy?
    • 1. Anti estrogenic
    • 2. Anti androgenic
    • 3. Glucocorticoids
  2. What is the Mech of action of Tamoxifen?
    Toxicity?
    Analog?
    Blocks the Estrogen recepter (it is a weak estrogen)

    • - thromboembolic disease
    • - endometrial cancer
    • - hot flushes
    • - retinopathy

    Faslodex (destroys the recepter)
  3. Name some Aromatase Inhibitors
    Aminogluthemide

    • Third Generations
    • anastrozole
    • letrozole
    • exemestane
  4. When would you use Tamoxifen verses Aromatase Inhibators?
    Tamoxifen--- used in both the pre and post menopausal settings.

    Aromatase Inhibitors--- only be used in the post menopausal settings when the adrenal gland is the mojor source of the estrogen production.
  5. Androgen Receptor Blockers are?
    what is the toxicity?
    • Flutamide
    • Bicalutamide

    • Toxicity:
    • - hot flushes
    • - impotence
    • ** andropause (in men)
  6. LHRH analogs?
    What is there Mech of action?
    when is it used?
    Toxicity?
    Leuprolide and Goserelin

    Decreases the pituitary release of both LH and FSH--> decreased estrogen and testosterone

    Prostate and breast cancers

    Flare effect, Impotence
  7. What are the uses of Corticalsteroids?

    What are some of the Toxicities?
    • - anti-nauseant
    • - appetite stimulant
    • - decreases cerebral edema
    • - co-analgesic
    • ___________________
    • - fluid retention
    • - glucose intolerance
    • - proximal myopathy
    • - insomnia
    • - immunosuppression
    • - increased appetite
    • - skin changes
    • - stress ulcers
  8. Name some of the Tyrosine kinase inhibitors
    • 1. EGFR (HER-2)
    • -Lapetinib
    • 2. EGFR (non HER-2)
    • -Gefitinib
    • -Eriotinib
    • 3. VEGF
    • -Sunitinib
    • -Sorafanib
    • 3. Product of mutated Oncogene
    • -Imatinib
  9. What is the Mech of action of Imatinib?

    Uses?
    Toxicity?
    -Inhibits TK activity or the protein product or BCR:ALB oncogene seen in CML

    • CML
    • GI stromal Tumors (expression c-KIt)

    Myalgia, Diarrhea, fluid retention
  10. Name some Mono clonal antibody EGFR target drugs?
    • 1. trastuzumab
    • HER-2 expressing Breast cancers
    • Cardiac toxicity
    • 2. cetuximab
    • k-ras wild-type colon cancer
    • 3. panitunumab
    • k-ras wild-type colon cancer
  11. Monoclonal antibodies with VEGF (receptor) target
    • bevacizumab
    • - Colon cancer
    • - Wound healing toxicity
  12. Monoclonal antibodies for Lymphocyte receptors
    • 1. CD 20 – rituxumab
    • -B-cell lymphoma

    • 2. CD 52 – alemtuzumab
    • -B-cell lymphoma
  13. temsirolimus and everolimus
    M-TOR inhibitor
  14. Proteosome inhitition?

    Uses?
    - Inhibited by bortezomib

    • - activity:
    • - multiple myeloma
    • - mantle cell lymphoma
  15. What are some Biologics?
    • •Interferons
    • •Interleukins
    • •Tumor necrosis factors
  16. What is the Mech of action of the interferons?

    Uses?
    Toxicity?
    • - attempt to control human
    • tumors by replicating this “interfering” property

    Uses: Melanoma, RCC, Hairy cell leukemia, T-cell lymphoma, CML

    Toxicity: Flu like symptoms, Myelosupression,
  17. What are some Common Methodes of Tumor cell resistance to Chemotheropy?
    • 1. increased expression of target proteins
    • 2. increased DNA repair
    • 3. failure of drugs to enter a cell or
    • increased efflux from cell regulated by multidrug resistance gene
    • 4. inability of drug to penetrate tumor
    • 5. target protein no longer available
    • 6. target molecule altered
    • 7. formation of trapping agent
    • 8. decreased activation of prodrug
  18. What are some Stratagies to Prevent resistance?
    • 1. combination chemotherapy
    • 2. dose intensity (1st does most important)
    • 3. agents to reverse resistance
  19. Resistance to Chemo may be inherited or aquired. Give examples
    • •May be inherent
    • eg. pancreatic cancer and gliomas

    • •May be acquired
    • eg. lymphoma and melanoma

What would you like to do?

Home > Flashcards > Print Preview