Pharm II (Diuretics Ia)
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What are the Mechanisms for Na+ absorption throughout the Nephron?
- PT- NaHCO3
- LH- Na/K/2Cl Symport
- CT- Na/K channel
What is the location of the Strongest and most efficatious Diuretics?
in the LH, becaues it has less compensation later on.
What are the Inhibitors of Na+ K+2Cl Co-transport?
What is the Efficacy?
- High eficacy
What are the Inhibitors of Na-Cl Co-transport?
What is the efficacy?
Chlorothiazide, Chlorthalidone, Metolazone and Indapamide (thiazide like diuretic).
Diuretics that act in the PT,LH,DT cause some degree of compensation in the CT. What is the primary Toxicity of these diuretics?
- -Hypokalcemia--> can cause Arrythmias
- -Metabolic Alkalosos
Carbonic anhydrase inhibitor diuretic
Does NOT cause Alkalosis
Potassium sparing diuretics
Where is its action?
When is this used?
- Collecting Duct action
- Aldosterone antagonist :
Used in 2ary Aldosterone release from Heart faliure
Inhibitors of renal epithelial Na channel
What are these used for?
Used for Ascities in Hepatic faluire
What is Furosemide?
What will intravenous use cause?
What is this the DOC for?
Inhibitors of Na+ K+ 2Cl Co-transport a High ceiling loop diuretic.
- -Thick ascending loop of Henle
- -Mild alkalosis at high dose
- -rapid increase in systemic venous capacitance and decrease left ventricular filling pressure
What does it increase?
What can be seen?
What is a common toxicity seen in intravenous administration?
- -Increases calcium excretion
- -Hyperglycemia and hyperuricemia can be occasionally seen with loop diuretics.
What drug shouldnt be given with Furosemide?
Aminoglycosides, because both cause ototoxicity.
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