Medchem Exam1

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Anonymous
ID:
5932
Filename:
Medchem Exam1
Updated:
2010-02-02 20:15:07
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Cardiovascular Agents
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Cardiovascular agents
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  1. Renin-Angiotensin system participates in pathophysiology by
    • Controlling Arterial blood pressure
    • Renin converts Angiotensin to Angiotensin 1
    • ACE Converts Angiotensin 1 to Angiotensin 2
  2. Methods to decrease high blood pressure due to angiotensin II
    • Inhibit ACE
    • Block binding site on AT1 receptor => ARB
    • AT1 receptor = GPCR
  3. 3 major effectos of angiotensin II
    • Altered peripheral resistance (rapid)
    • Altered renal function (slow)
    • Altered cardiovascular structure
  4. Drug Classes
    • Ace Inhibitors
    • Carboxyalkanoyl or mercaptoalkanoyl derivitives
    • ARBs
  5. 4 Drug classes used to treat Myocardial Ischemia (angina pectoris)
    • B-Adrenergic receptor antagonists
    • Nitrovasodilators
    • Ca2+Channel Antagonists
    • Statins
  6. Organic Nitrates
    • Prodrug of Nitric Oxide
    • Vasodilation
    • Low Molecular mass: moderately volatile, oily liquid
    • High Molecular mass: solid
  7. Ca2+ Channel Antagonists
    • Block contraction of muscle
    • Bind to alpha-1 subunit of L-type Ca2+ Channel
  8. Five classes of Ca2+ Antagonists
    • Phenylalkylamines
    • Benzothiazepines
    • Dihydropyridines
    • Diphenylpiperazines
    • Diarylaminopropylamines
  9. Statins
    • Competitive inhibitor of HMG-CoA Reductace
    • -Rate limiting step in cholesterol biosynthesis
    • -OH in the 3 position
    • Lactone insoluble, must convert to acid
  10. Mechanism of action for MI drugs
    • Improve balance of myocardial oxygen supply and demand
    • -vasodilation
    • -reduce cardiac work

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