Explain the control of ADH secretion by negative feedback.
ADH, or antidiuretic hormone, acts on kidneys to promote water retention. It decreases urine output by increasing water reabsorption in the collecting duct. Osmoreceptors in the hypothalamus detect high solute concentration in the blood. Neurosecretory cells produce ADH, which is stored in the posterior pituitary. When osmoreceptors in the hypothalamus detect high solute concentration, ADH release from the posterior pituitary is triggered. When osmoreceptors detect normal blood solute levels, the production and secretion of ADH stop. This is negative feedback.