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1 st generation Cephalasoprin - Example and activity
Cefazolin: MSSS staph and strep. Has many community acquired E-coli, Klebsiella, Proteus
- - Skin and soft tissue infections
- - Some surgical prophalaxis
2 nd generation Cephalosporins?
- More active against Gram Negative less active against Gram positive some against gut anaerobes.
example: Cefoxitin (GI and gyn prophylaxis), Cefotetan
- H-Flu, Neisseria, and Gram positive.
Used for PID, Abd surgery.
3 rd generation Cephalasporins? Example and activity
Which three can cross the Blood brain Barrier ?
Which has activity against Pseudomonas?
N-Gonorrhea, H- influenzae, Enterobacteriacease (e-coli, klebsiella, proteus, Enterobacter and Serratia).
Ceftriaxone, Cefotaxime, Ceftazidime (crosses blood brain)
Pseudomonas activity: Ceftazidime
4th generation Cephalosporin
Same gram negative activity as 3rd generation and Gram positive coverage as 1st generation with limited anarobic coverage. Has activity against extended spectrum cephalosporin.