azathioprine(Imuran) is a purine analogue prodrug cleaved to mecaptopurine and inhibit synthesis of DNA,RNA, and protein
What are drug interactions with azathioprine?
concominant use with allopurinol will increase effect of azathioprine (when used together decrease dose by 65-75%)
What are disease interactions with azathioprine?
What are SE of azathioprine?
retinopathy, GI, neutropenia, thrombocytopenia
What is the MOA of mycophenolate mofetil?
brand name Cellcept belongs to antiproliferative agents, is metabolized to mycophenolic acid which cause noncompetitive reverse inhibition of inosine monophosphate dehydrogenase (critical enzyme in denovo pathway of purine synthesis) which is crucial during lymphocyte activations and proleferation
What are the drug interactions of mycophenolate mofetil?
cyclosporine, cholestyramine, colestipol and colesevelam, antacids, efficacy of brith control may be decreased
What are disease and mycophenolate mofetil interactions?
severe renal impairment
What are the SE of mycophenolate mofetil?
GI, leukopenia, thrombocytopenia, anemia
What is the MOA of mycophenolate sodium?
brand name is Myfortic, MOA is same as mycophenolate mofetil except it comes in delayed relase tabs. and that delivers the mycophenolic acid
What are drug interactions with mycophenolate sodium?
cholestyramine, antacids, efficacy of birth control may be decreased?
What are the disease and mycophenolate sodium interactions and SE of drug?
same as with mycophenolate mofetil
What IV corticosteroids are used with transplant drugs?
methylprednisolone and dexamethasone
What are oral corticosteroids that are used with transplant drugs?
prednisone, prednisolone, dexamethasone
What are the drug interactions with corticosteroids?
metabolized by CYP450;3A isoenzymes
same as with cyclosprine and tacrolimus
What are disease and corticosteroids interactions?