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Mechanism of Action
Reversibly blocks the action of cyclooxygenase which in turn prevents formation of prostaglandins. Causes analgesia equivalent to that of morphine sulfate
Acute moderate to severe pain
NSAID allergy, ASA sensitivity asthma, known peptic ulcer disease, recent GI bleed, renal failure, confirmed cerebrovascular bleeding, recent CABG, pregnancy
Use cautiously with CHF and cirrhosis patients due to renal failure
- GI bleeding
- Inhibition of platelet aggregation
- Acute renal failure
Potentiates medications that inhibit platelet aggregation
Dose and Route
Adult: 15-30 mg IV or 30-60 mg IM (single dose only)
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