Medchem Exam 1

Card Set Information

Author:
Anonymous
ID:
6115
Filename:
Medchem Exam 1
Updated:
2010-02-05 12:52:15
Tags:
Class III and IV Antineoplastic Agents
Folders:

Description:
Class III and IV Antineoplastic Agents
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Anonymous on FreezingBlue Flashcards. What would you like to do?


  1. Class III Natural Products
    • Antimitotic Drugs
    • DNA Topoisomerase Inhibitors
    • Antibiotics
    • Enzymes
  2. Antimitotic Drugs
    • Vinca Alkaloids
    • Taxanes
  3. DNA Topoisomerase Inhibitors
    • Camptothecins
    • Podophyllotoxins
  4. Antibiotics
    • Anthracycline
    • Dactinomycin/Actinomycin D
    • Bleomycin
    • Mitomycin
  5. Enzymes
    L-Asparaginase
  6. Vinca Alkaloids
    • block cells in mitosis by binding to B-tubulin and inhibiting its ability to polymerize with a-tubulin into microtubules.
    • M-Phase Specific
  7. Taxanes
    • Binds to site on B-Tubulin that promotes microtuble formation
    • M-Phase specific
  8. Camptothecins
    • Bind to and stabilize DNA topoisomerase I cleavable complex
    • S-Phase specific
  9. Podophyllotoxins
    • Form a ternary complex with topoisomerase II and DNA preventing resealing of the break.
    • S and G2 phase specific
  10. Anthracycline
    • form tripartite complex with topoisomerase II and DNA
    • Intercalate in DNA directly affecting transcription and replication
    • tetracyclic ring connected to daunosamine sugar.
    • S-Phase specific
  11. Dactinomycin/Actinomycin D
    • phenoxazone ring intercalates in DNA while polypeptide chains block transcription of DNA by RNA polymerase
    • S-Phase specific
  12. Bleomycin
    • DNA Cleaving antibiotic
    • Basic water soluble glycopeptides
    • S-phase specific
  13. Mitomycin
    • Bifunctional or trifunctional alkylating agent after activation
    • Radiosensitizer
    • Structure contains azaurdine group and quinone group with mitosane ring
    • Non-phase specific
  14. L-Asparaginase
    • Hydrolysis of Asparagine to aspartic acid and ammonia, depriving cells of asparagine necessary for growth
    • Non-phase specific.
  15. Class IV Antineoplastic Drugs : Miscellaneous Agents
    • Hydroxyurea
    • Differentiating Agents
    • Protein Tyrosine Kinase inhibitors
    • Proteasome Inhibitor
    • Monoclonal Antibodies
  16. Hydroxyurea
    • inhibits ribonucleoside diphosphate reductase
    • -conversion of ribonucleotides to deoxyribonucleotides
  17. Differentiating Agents
    • Vitamin D, Retinoids, HDAC inhibitors
    • Induce differentiation of cancerous cells
  18. Protein Tyrosine Kinase inhibitors
    • Imatinib/Gleevec
    • Gefitinib
    • Erlotinib/Tarceva
  19. Imatinib/Gleevec
    Inhibits BCR-ABL Kinase
  20. Gefitinib
    Inhibits EGFR/ErbB1/Her1 Kinase
  21. Erlotinib/Tarceva
    Inhibits EGFR/ErbB1/Her1 Kinase
  22. Bortezomib
    • Reversible inhibitor of chymotrypsin-like activity of proteosome
    • -disrupts signaling cascades
  23. Proteasome Inhibitors
    Bortezomib
  24. Monoclonal Antibodies
    • Trastuzumab/Herceptin
    • Bevacizumab/Avastin
  25. Trastuzumab/Herceptin
    Inhibits dimerization of ErbB2/Her2 kinase
  26. Bevacizumab/Avastin
    Inhibits VEGF, blocking angiogenesis

What would you like to do?

Home > Flashcards > Print Preview