Toxicology Exam 1

Card Set Information

Author:
Rx2013
ID:
61153
Filename:
Toxicology Exam 1
Updated:
2011-01-21 17:22:43
Tags:
Dr Badr\'s lecture
Folders:

Description:
Dr. Badr's lecture 1/19
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Rx2013 on FreezingBlue Flashcards. What would you like to do?


  1. study to identify the specific target molecule which is attacked by a toxin
    molecular mechanisms
  2. Toxins may be
    specific and non-specific
  3. Example of a non-specific toxin
    sulfuric acid
  4. Direct effect
    attack molecule of the retina resulting in blindness
  5. Indirect effect
    attack the pancrease resulting in diabetes
  6. Direct targets of toxins
    • Proteins
    • Lipids
    • Nucleic Acids
  7. Proteins that may be targeted by toxins
    • Enzymes
    • Receptors/Ion Channels
    • Transport Proteins
  8. Enzymes that may be targeted by toxins
    • Acetylcholine esterase
    • Mitochondrial enzymes
  9. Organophosphates
    • methylparoxon
    • ties up ACHE
  10. Example of enzyme aging
    ACHE-Phosphate loses a methyl group resuling in a fre --O
  11. Three types of chemicals to help enzyme recovery
    • Hydroxylamine
    • Hydroxamic acid derivatives
    • Oximes
    • (all contain N-OH group)
  12. Oximes
    • Pralidoxime (2-PAM)
    • more efficient than water to recover ACHE
  13. Mitochondrial enzymes that may be targeted by toxins
    • Cytochrome oxidase
    • ATPase
  14. Complex I of the respiratory chain deals with
    NADH - linked molecules
  15. Complex II of the mitochondrial respiratory chain deals with
    FADH linked molecules
  16. Inhibitor of Complex I (NADH complex)
    rotenone
  17. Amytal
    barbituric acid derivative
  18. Oligomycin
    inhibitor of ATPase
  19. Cyanide
    inhibitor of cytochrome oxidase complex
  20. Tetrodotoxin
    sodium channel inhibitor
  21. Effects of toxins on receptors/ion channels
    • increased or decreased ions moving through the channels
    • intracellular enzyme activity increased or reduced
    • gene expression may be altered
  22. Most abundant protein carrier in the body is
    • hemoglobin
    • carries oxygen
  23. Oxidized form of iron
    ferric
  24. reduced form of iron
    ferrous
  25. CO binds heme ____x better than O
    20
  26. Oxidized iron in hemoglobin is called
    • methemoglobin
    • will not bind oxygen
    • can sometimes be beneficial

What would you like to do?

Home > Flashcards > Print Preview