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measure of the extent of drug absorption. (usually compares routes)
Passage of drugs across body and cell membranes in order to reach their site of action and the target receptors.
3 general mechanisms for drug passage:
- Passive Diffusion
- Carrier Mediated Transport
Penn in the renal tubules is an example of ...
carrier mediated transport
route for drug passage, either through aqueous pores or through the liprprotein region
The brain and testis capillaries have an absence of...
Two types of passive diffusion:
Conditions of Passive Diffusion
- Small- penetration by filtration though pores
- Large- Large pore, or unionized and lipid soluble
Major Route for drug passage:
Which type of carrier mediated transport involves the use of E
What barriers exist to protect the brain?
- Blood-CSF (choroid plexus)
- Blood-Brain (cerebral cap)
- Glial Cell Layer
A high partition coefficient indicates...
In general, it is the ____ drug that passes across the membrane
Ion Trapping, in general, leads to...
the accumulation of acids of the basic side of a membrane and vice versa
Peak isn't an actual equilibrium b/c elimination and absorption begins at the same time
processes to facilitate excretion and render drugs less potent
Drugs that are inactive until metabolized
3 Examples of pro-drugs:
- Protonsil -> sulfanilamide
- Hetacillin -> ampicillin
- Febantel -> fenbendazole
Drugs metabolized in the liver tend to be
biotransformation yields products that are more ___ than their parent compounds
polar (water soluble)
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