DNA repair

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  1. What is mutated in HNPCC
    • MSH2
    • MLH1
  2. What sequences are mutated that identify parent strands?
    GATC
  3. What results from faulty mismatch repair?
    HNPCC
  4. What are the steps in base-excision repair?
    • removal of base by a specific N-glycosylase
    • removal of sugar and phosphate by AP-endonuclease and deoxyribose phosphate lyase
    • DNA polymerase
    • DNA ligase
  5. Xeroderma pigmentosa results from a mutation in what gene?
    XPA-XPG
  6. Which 2 proteins control the entry of cell from G1 to S phase?
    Rb and p53
  7. Microsatellite instability often leads to what condition?
    HNPCC
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ID
61384
Card Set
DNA repair
Description
DNA repair
Updated
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