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what is a drug that interferes with the action of an agonist?
t/f an antagonist has no effect in the absence of an agonist
how can antagonists be classified?
what are the two types of receptor antagonists
competitive and noncompetitive antagonists
what type of antagonist has affinity for a receptor but no efficacy (Can't cause an effect)
receptor competitive antagonist
does a competitive antagonist form a reversible or irreversible drug receptor complex
the presence of a _______ antagonist reduces the potency of the agonist
what type of antagonist prevents receptor activation?
receptor noncompetitive antagonists
does a noncompetitive antagonist produce a reversible or irreversible drug receptor complex
the presence of a _____ antagonist reduces the efficacy of the agonist
what type of receptor antagonist reduces the potency of the agonist? the efficacy?
what two forms can a nonreceptor antagonist be?
a ______ antagonist may either bind a molecule at some point in the activation pathway or directly inhibit the agonist
a ____ antagonist activates pathways that oppose the action of the agonist
what have both agonistic and antagonistic properties?
when a mixed agonist-antagonist is used alone how will the drug behave?
as an agonist
when another drug is taken with a mixed agonist-antagonist and competes for the same receptor site how will it act?
as an antagonist
what are the two was a receptor is classified?
type of interacting drug receptor
specific physiologic response
how are receptors subclassified?
effects of agonist in presence or antagonist
how many receptor types or subtypes are on a cell
t/f any drug at high enough concentration can produce a toxic effect (overdose)
what refers to the undesirable effects associated with the administration of therapeutic dosages of drugs
what are the adverse effects of toxicity be? (2)
exaggeration of direct effects seen at high doses
multiple concurrent adverse effects occurring at therapeutic dosage levels
the dose of a drug required to produce a desired response in 50% of the individuals with in the same population is called?
median effective dose (ED50)
if death is the measured end point how is the ED50 expressed?
median lethal dose LD50
what does a steep dose response curve indicate between minimal and maximal effects?
narrow dosage range
how is the margin of safety of a drug expressed?
therapeutic index TI
what is the TI an actual ratio of?
the _____ the TI the safer the drug
two similar drugs A and B are being compared. The therapeutic index is computed for both of them the TI for drug A is 8.5 and the TI for drug B is 10. Which drug is relatively more safe?
Drug B-higher TI
chapter 2 part 2 (starts at antagonists)