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2011-01-24 02:05:15

chapter 2 part 2 (starts at antagonists)
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  1. what is a drug that interferes with the action of an agonist?
  2. t/f an antagonist has no effect in the absence of an agonist
  3. how can antagonists be classified?
    • receptor
    • nonreceptor
  4. what are the two types of receptor antagonists
    competitive and noncompetitive antagonists
  5. what type of antagonist has affinity for a receptor but no efficacy (Can't cause an effect)
    receptor competitive antagonist
  6. does a competitive antagonist form a reversible or irreversible drug receptor complex
  7. the presence of a _______ antagonist reduces the potency of the agonist
  8. what type of antagonist prevents receptor activation?
    receptor noncompetitive antagonists
  9. does a noncompetitive antagonist produce a reversible or irreversible drug receptor complex
  10. the presence of a _____ antagonist reduces the efficacy of the agonist
  11. what type of receptor antagonist reduces the potency of the agonist? the efficacy?
    • potency-competitive
    • efficacy-non competitive
  12. what two forms can a nonreceptor antagonist be?
    • chemical
    • physical
  13. a ______ antagonist may either bind a molecule at some point in the activation pathway or directly inhibit the agonist
  14. a ____ antagonist activates pathways that oppose the action of the agonist
  15. what have both agonistic and antagonistic properties?
    mixed agonist-antagonists
  16. when a mixed agonist-antagonist is used alone how will the drug behave?
    as an agonist
  17. when another drug is taken with a mixed agonist-antagonist and competes for the same receptor site how will it act?
    as an antagonist
  18. what are the two was a receptor is classified?
    • type of interacting drug receptor
    • specific physiologic response
  19. how are receptors subclassified?
    effects of agonist in presence or antagonist
  20. how many receptor types or subtypes are on a cell
  21. t/f any drug at high enough concentration can produce a toxic effect (overdose)
  22. what refers to the undesirable effects associated with the administration of therapeutic dosages of drugs
  23. what are the adverse effects of toxicity be? (2)
    • exaggeration of direct effects seen at high doses
    • multiple concurrent adverse effects occurring at therapeutic dosage levels
  24. the dose of a drug required to produce a desired response in 50% of the individuals with in the same population is called?
    median effective dose (ED50)
  25. if death is the measured end point how is the ED50 expressed?
    median lethal dose LD50
  26. what does a steep dose response curve indicate between minimal and maximal effects?
    narrow dosage range
  27. how is the margin of safety of a drug expressed?
    therapeutic index TI
  28. what is the TI an actual ratio of?
  29. the _____ the TI the safer the drug
  30. two similar drugs A and B are being compared. The therapeutic index is computed for both of them the TI for drug A is 8.5 and the TI for drug B is 10. Which drug is relatively more safe?
    Drug B-higher TI