receptor sites are always occupied so you need a higher amt to produce same effect
Tolerance resulting from accelerated drug metabolism.
This form of tolerance is brought about by the ability of certain drugs (eg, barbiturates) to induce synthesis of hepatic drug-metabolizing enzymes, thereby causing rates of drug metabolism to increase.
Because of increased metabolism, dosage must be increased to maintain therapeutic drug levels.
tolerance that can be defined as a reduction in drug responsiveness brought on by repeated dosing over a short time.
more intense effects and possible toxicity could be a result of malnutrition because
Lower amounts of plasma proteins (albumin) causing levels of free drug to rise