Immuno, Innate Imm: Neut, MO

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Author:
HLW
ID:
62058
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Immuno, Innate Imm: Neut, MO
Updated:
2011-01-26 15:50:54
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Immuno
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Description:
Innate Imm
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  1. Ways in which the innate immune sys responds (4):
    • Inflammation
    • Phagocytic Cells
    • NK Cells
    • Soluble Defense Factors
  2. Functions of inflammation?
    Activation and directed migration of cells (Neutrophils and macrophages
  3. Phagocytic Cells include:
    • Monocytes(tissue)/Macrophages(blood)
    • Granulocytes (i.e. neutrophils)
  4. Soluble Defense Factors include:
    • Enzymes
    • Defensins
    • Interferons
    • Complement Proteins
  5. Functions of complement proteins (3):
    • Cell Lysis
    • Chemotaxis
    • Opsonins
  6. Cytokines-
    Proteins that mediate cellular interactions and regulate cell growth and secretion.
  7. Interferons-
    Cytokines that interfere with viral replication (soluble defense factor)
  8. Complement Proteins-
    serum and cell surface proteins that can be activated by innate/acquired immune mech (soluble defense factor)
  9. Defensins-
    Bacterial Peptides for killing bacteria
  10. Functions of Complement Proteins:
    • Cell Lysis
    • Chemotaxis
    • Coat Microbes for phagocytosis (opsonins)
  11. Elevated neutrophils-
    Neutrophilia
  12. Neutrophils reside in...
    • Circulating Pool (CP)
    • Marginal Pool (MP)
  13. Neutrophil life span
    6-10 hrs - a few days
  14. Functions of Integrins (2):
    Cell surface protein on neutrophil that binds it to the capillary endothelium
  15. Two receptor types on antibody:
    • Fab - binds antigen
    • Fc - binds complement protein
  16. Steps of phagocytosis
    • Chemotaxis
    • (adhesion and emigration)
    • Adherence to microbe
    • Ingestion
    • Destruction
  17. Chemokines-
    Cytokines that attract specific cells and mediate inflammatory response (for phagocytosis)
  18. Opsonins-
    Proteins that promote binding of pathogens to phagocytes
  19. Two ways in which Destruction is carried out:
    • Oxygen DEP killing with phagosome
    • Oxygen INDEP killing with phagoLYSOsome
  20. Bacteria that can survive inside macrophages (5):
    • Mycobacterium bovis
    • Rhodococcus equi
    • Brucella abortus
    • Listeria monocytogenes
    • Salmonella typhimurium
  21. BW seen w/ Leukocyte Adhesion Deficiency
    • Neutrophilia (+)
    • Leukocytosis (+)
    • Monocytosis (+)
  22. BLAD P's present:
    • Gingivitis
    • Pneumonia
  23. Eosinophil tasks:
    • Phagocytosis (minor)
    • Killing parasites (major)
  24. Basophil Tasks:
    • Inflammation
    • Immune Response
    • Allergic Response
  25. Macrophage life span:
    Long (w/ sustained phagocytosis)
  26. Steroids and PG's down-regulate...
    Macrophages
  27. Macrophage Functions (4):
    • Phagocytosis
    • Secretion
    • Wound Healing
    • *Antigen Presenting
  28. Cytokines secreted by macrophages (2):
    • Monokines
    • Interleukins
  29. Interleukins-
    Proteins that act as growth and differentiation factors for cells of the immune system
  30. Interleukin TNF-a is produced by both ____ & ____
    Macrophages and Mast Cells (inflammatory mediator)
  31. Removal of...

    Large Antigens:
    Small Antigens:
    • Large Antigens: Phagocyte -> Spleen
    • Small Antigens: Soluble Immune complex -> Macrophage
  32. PAMP-
    • Recognizable molecules on microbes that are essential for the survival of the microbe
    • (Pathogen-Associated Membrane Patterns)
  33. PRR-
    • Receptors on macrophages that recognize groups of pathogens
    • (Pattern Recognition Receptors)
  34. *TLR-
    • Type of PRR (receptor on macrophages) that interacts with PAMP (molecule on microbes)
    • (Toll-Like Receptor)
  35. Interaction btw. PRR and PAMP=>
    • Phagocytosis
    • Activation of cytokines that induce inflammation
  36. NK cells lack receptors for:
    • FcR (Fc part of antibody)
    • Complement Proteins
  37. NK cells target cells that lack ___ and those that have ___ & ___
    • ...lack MCH-I
    • ...have FcR & IFN-a
    • (IFN = interferon on virally infected cells)
  38. NK cells kill by
    Apoptosis

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