Card Set Information
molecular structures that the immune sys can recognize and respond to
Ag is a substance capable of....
Inducing a SPECIFIC immune response
Interacting with the products of that response
Antigens the induce a response are recognized by (2):
Antigens can interact with (4):
TCR (T-Cell Receptor on T-Lymphs)
The ability of an antigen to bind with immune components
The ability of an antigen to induce an immune response
Properties of good immunogens (4):
Ex. of poor immunogens, based on complexity (
Polymers (plastics, Bacillus anthracis, carbs)
Part of the antigen that is recognized by the antibody, TCR or BCR
Types of epitopes (2):
Conformational (recognition based on folding)
Linear (Recognized based on AA sequence)
An acquired immune response to the epitope of a similar bacteria or virus
Two bacteria that can give false pos. due to cross reactivity?
Brucella abortus (bad)
Yersinia enterocolitica (insignificant)
Small, antigenic molcules that can only induce an immune response if they are bound to a carrier protein
Most microbial immunogenic molecules are...
(some carbs and lipids)
Where a microbes replicates, outside/inside of the cell
Intracellular pathogens include...
most viruses and some bacteria
(Can still survive outside of cell)
Extracellular pathogens include...
Most bacteria and parasites
Intracellular Bacteria (4):
Where the antigen is made
(vs extra/intracellular pathogens)
Ex. of an endogenous antigen:
Ex. of a bacteria which has a capsule that protects it from immune response
Two defining features of Mycobacterium, Rhodococcus equi, Listeria Monocytogenes and Brucella abortus
Viruses use the host's ___ to make ___
It's difficult to create an HIV Vx b/c...
the envelope can vary it's antigenicty