Immuno: Ag

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Immuno: Ag
2011-01-26 19:54:25

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  1. Ag-
    molecular structures that the immune sys can recognize and respond to
  2. Ag is a substance capable of....
    • Inducing a SPECIFIC immune response
    • Interacting with the products of that response
  3. Antigens the induce a response are recognized by (2):
    • Antibody
    • T-Lymphocytes
  4. Antigens can interact with (4):
    • Antibody
    • TCR (T-Cell Receptor on T-Lymphs)
    • BCR
    • MHC
  5. Antigenicity-
    The ability of an antigen to bind with immune components
  6. Immunogenicity-
    The ability of an antigen to induce an immune response
  7. Properties of good immunogens (4):
    • Small (<1kDa)
    • Complex
    • Moderate Stability
    • Foreign
  8. Ex. of poor immunogens, based on complexity (
    • Lipids
    • Nucleic Acids
    • Polymers (plastics, Bacillus anthracis, carbs)
  9. Epitope-
    Part of the antigen that is recognized by the antibody, TCR or BCR
  10. Types of epitopes (2):
    • Conformational (recognition based on folding)
    • Linear (Recognized based on AA sequence)
  11. Cross Reactions-
    An acquired immune response to the epitope of a similar bacteria or virus
  12. Two bacteria that can give false pos. due to cross reactivity?
    • Brucella abortus (bad)
    • Yersinia enterocolitica (insignificant)
  13. Haptens-
    Small, antigenic molcules that can only induce an immune response if they are bound to a carrier protein
  14. Most microbial immunogenic molecules are...
    • Proteins
    • (some carbs and lipids)
  15. Extra/Intracellular pathogens-
    Where a microbes replicates, outside/inside of the cell
  16. Intracellular pathogens include...
    • most viruses and some bacteria
    • (Can still survive outside of cell)
  17. Extracellular pathogens include...
    Most bacteria and parasites
  18. Intracellular Bacteria (4):
    • Mycobacterium
    • Rhodococcus equi
    • Listeria Monocytogenes
    • Brucella abortus
  19. Ex/Endogenous Antigens-
    • Where the antigen is made
    • (vs extra/intracellular pathogens)
  20. Ex. of an endogenous antigen:
    Mycobacterium bovis
  21. Ex. of a bacteria which has a capsule that protects it from immune response
    Bacillus anthracis
  22. Two defining features of Mycobacterium, Rhodococcus equi, Listeria Monocytogenes and Brucella abortus
    • Intracellular Pathogens
    • Endogenous Antigens
  23. Viruses use the host's ___ to make ___
    • RNA
    • Virions
  24. It's difficult to create an HIV Vx b/c...
    the envelope can vary it's antigenicty