HISTOLOGY-Lecture 1-Cell Membrane

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Author:
lfield5
ID:
62776
Filename:
HISTOLOGY-Lecture 1-Cell Membrane
Updated:
2011-01-29 14:00:11
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HISTOLOGY
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Lecture 1-Cell Membrane
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  1. Cell Membrane - function
    • 1. maintain structural integrity of cell
    • 2. semipermeability – controls what get in/out
    • 3. regulates cell-cell interactions
    • 4. recognition –receptors/antigens/foreign,altered cells
    • 5. interface between cytoplasm & external milieu
    • 6. establish transport systems for molecules
    • 7. transduce extracellular signals -> intracellularly
  2. Cell Membrane - structure (components)
    unit membrane – fluid mosaic model

    • phospholipid structure
    • leaflet structure
    • glycocalyx (cell coat)
  3. Phospholipid Structure
    increases fluidity

    hydrophilic head composed of (1) + nitrogenousgroup glycerol

    • phosphategroup
    • 2 hydrophobic glycerol tails composed of fatty acyl tails
  4. Leaflet Structure
    • biphospholipid (unit membrane)
    • a)inner leaflet - cytoplasm - P-face – outer surface
    • b)outer leaflet - extracellular - E-face – inner surface
    • embedded
    • integral (transmembrane) proteins span the membrane
    • hydrophilic AA – in/out
    • hydrophobic AA – within
    • peripheral multipass proteins on the cytoplasmic side of membrane
    • cholesterol
    • maintain integrity of membrane by increasing and decreasing fluidity
    • involved in cell signaling
  5. Glycocalyx (cell coat)
    carbohydrate chains that coat cell surface

    • glycoprotein -carbohydrate
    • chains attached to transmembrane protein

    glycolipid - carbohydrate chains attached to phospholipid molecule

    • provides protection from
    • a) inappropriate proteins
    • b) chemical injury
    • c) physical injury
    • d) cell-cell recognition
    • e) adhesion
  6. glycolipid
    carbohydrate chains attached to phospholipid molecule
  7. glycoprotein
    carbohydrate chains attached to transmembrane protein
  8. cholesterol
    maintains integrity of membrane by increasing and decreasing fluidityinvolved in cell signaling
  9. integral (transmembrane) proteins
    • span the membrane
    • hydrophilic amino acid – in/out
    • hydrophobic amino acid – within
    • peripheral multipass proteins on the cytoplasmic side of membrane

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