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. What would you like to do?
Oubain--blocks sodium/potassium pump
What produces Ach in the CNS?
Deficiency of Ach in the CNS?
Block K+ ion channel
Blocks Na+ ion channel
Diagnosis for Myesthenia Gravis?
Endrophonium ( short term anti Achesterase)
Treatment for Myesthenia Gravis?
Cure for Myesthenia Gravis?
Mode of action of Sarin Gas?
Permanantly deactives Achesterase
What determines if the binding of Ach will have excitatory or inhibitory effect?
- Ion channels on the post synaptic membrane
What nt is always excitatory in the CNS?
What nt is always inhibitory in the CNS?
Post synaptic potentials are ligand or voltage dependent?
Action potentials are ligand or voltage dependent?
What limits frequency of AP?
Absolute refractory Periods
Voltage gated channels are only present on what part of the neuron?
node of ranvier
The delay between AP and PSP is commonly called?
Short term memory is dependent on what?
What is presynaptic facilitation?
nt binding decreases K+ permeability, leaving + inside, depolarizing the membrane--membrane is hyperexcitable
What is presynaptic inhibition?
nt binding increases Cl- permeability resulting in hyperpolarization of the membrane.---harder to depolarize
What is an ionotropic hormone receptor?
nt binding activates ion channels---quick
What is an metabotropic hormone receptor?
nt binding activates a 2nd messenger which then opens and ion channel---long activation and long duration
What is the more of action of Botulism toxin?
B. toxin prevents release of Ach from the presynaptic membrane
Black widow spider venom has what effect on the NMJ?
- increases influx of Ca
- increases the release of Ach
Treatment for nerve gas (sarin)
What eleminates Epi and Norepinephrine in the cleft?
An Amine pump
What nt is decreased in clinical depression?
Whats a common treatment for clinical depression?
SSRI---selective serotonin reuptake inhibitor
Which GABA receptor is ionotropic?
What are the 2 enzymes that eliminate residual catecholamines in the cleft (epi and noepi)
LSD is an agonist of what hormone?
Aspartate is inhibitory of excitatory?
What receptor has a chloride channel in the middle?
What effect do EtOH, barbituaries, benzodiazopan(valium) have on the GABA receptor?
bind to binding sites other than GABA and potentiate the effects of GABA
Large molecule peptide nt are ?
Endorphins and Enkephalins
What receptor do endorphins and enkephalins bind to?
Opium mimics the effects of what 2 large nt?
endorphins and enkephalins
Substance P mediates what ?
Alpha motor neurons innervate what fibers?
Gamma motor neurons innervate what muscle fibers?
Gamma motor neuron innervates the fiber where?
at the striated parts
Type IA innervates chain and bag receptors or just one of them?
Type II innervates chain and bag receptors or just one?
What are the characteristics between motor fibers?
I, II, III, IV?
- I--large diameter..myelinated..fast conductance
- II--between one and 3
- III- small diameter...low myelination..slow conductance
- IV--no myelination..
- ..all have shwanna cells associated with them
What is the purpose of Motor afferent fibers?
Tell the CNS about the motor unit/system
What info does Type II fiber relays?
- --length of muscle
- --change in length
What info does Type IA relay to CNS?
- ---length of muscle
- --- change in length
- --- rate of change in length
Which muscle fiber is clinically insignificant?
Which motor neuron has a corkscrew shape?
What would you like to do?
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