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What are the 2 families of the eicosanoid molecules?
the prostaglandins and the leukotrienes
Where are the leukotrienes and prostaglandins found?
in virtually all body cells except rbc's
what do prostaglandins and leukotrienes do?
act as local hormones in response to chemical or mechanical stimuli
What role do the prostaglandins have?
They alter smooth muscle contraction, glandular secretions, blood flow, reproductive processes, platelet function, respiration, inerve impulse transmission, lipid metabolism and immune response...they also have roles in promoting inflammation and fever and in intensifying pain
How does aspirin work?
by inhibiting a key enzyme in prostaglandin synthesis without affecting synthesis of leukotrienes
What play important roles in tissue development, growth and repair?
How do growth factors work?
they cause growth by stimulating cell division
What does mitogenic mean?
growth by stimulating cell division
Are growth factors central or local?
they are local, either autocrines or paracrines
What are the 6 important growth factors?
platelet-derived growth factor
fibroblast growth factor
nerve growth factor
tumor angiogenesis factors
transforming growth factors
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