i. Major risk factors—age, family history, abnormal lipids, cigarette smoking, hypertension, diabetes, obesity
ii. Risk factors are the same for atherosclerosis of other vessels discussed in chapter 15.
iii. When plaques narrow arterial lumen by 75% or so, symptoms begin to develop.
- iv. Acute coronary syndromes (ACS)—are almost always associated with acute disruption of a vulnerable plaque and include:
- 1. Unstable angina
- 2. MI (myocardial infarction)
- 3. Sudden cardiac death (unexpected death within 1 hour from the onset of symptoms)—usually (not always) due to CAD
v. Coronary vasospasm—plays an important role in patients with anginal signs & symptoms but no significant atherosclerotic coronary disease: so-called Prinzmetal or variant angina.