usmle

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Author:
icbcc
ID:
63774
Filename:
usmle
Updated:
2011-02-02 22:28:56
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usmle
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Qbank Kaplan
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  1. Lepirudin, bivalirudin
    direct inhibitor of thrombin, unlike heparin it's action is independent of antithrombin 3. Neutralizes the thrombin, including the thrombin entrapped in previously formed clot
  2. sumatriptan
    • 5-HT 1b/1d agonist, causes vasoconstriction, inhibition of trigeminal activation and vasoactive peptide release.
    • Use for cluster headache attacks.
  3. ALS, Rx to extend the life
    Riluzole, which inhibits glutamatergic neurotransmission
  4. 1.chloramphenicol
    2.SE
    • 1.inhibits 50S peptidyltrasferase activity
    • 2. Anemia(dose dep), aplastic anemia( dose indep),
    • gray baby syndrome( in infants because they lack liver UDP glucuronyl transferase)
  5. Rifampin 4R's
    • RNA polymerase inhibitor
    • Revs up microsomal P-450
    • Red/orange body fluids
    • Rapid resistance if used alone
  6. cytarabine
    Rx
    SE
    • pyrimidine antagonist- inhibition of DNA polymerase
    • AML, ALL, high-grade non-Hodgkin lymphoma
    • leukopenia, thrombocytopenia, megalobl.anemia
  7. trientine
    copper chelating agent for Wilson disease

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