BASIC PRINCIPLES-2

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Author:
dr.fizzle
ID:
63934
Filename:
BASIC PRINCIPLES-2
Updated:
2011-02-06 19:04:57
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  1. What are the 5 mechanisms for signaling?
    • 1- Intracellular receptors for lipid-soluble agents
    • 2- Ligand-Regulated transmembrane enzymes
    • 3- Cytokine Receptors
    • 4- Ligand-gated ion channels
    • 5- G-proteins & second messengers
  2. What receptor type do these drugs work on:

    nitric oxide, corticosteroids, sex horomones, thyroid horomone, vitamin D
    Intracellular receptors for lipid-soluble agents
  3. What receptor type do these drugs work on:

    insulin, EGF (epidermal growth factor), PDGF (platelet-derived growth factor), TFG-beta (transforming growth factor-beta)
    Ligand-regulated transmembrane enzymes (including RTKs)
  4. Specific inhibitors of growth factor-activated _______ ________ _______ are effective therapeutic agents in treating cancer.
    receptor tyrosine kinases
  5. True or false, cytokine receptors do NOT have intrinsic kinase activity.
    True
  6. What receptor type do these drugs work on:

    acetylcholine, serotonin, gamma-aminobutyric acid (GABA), excitatory amino acids
    Ligand-gated Ion Channels
  7. What receptor type do these drugs work on:

    catecholamines, histamine, vasopressin, glucagon, FSH, LH, thyrotropin, PTH
    G-Protein Receptor
  8. Which enzyme domains are invovled with ligand-regulated transmembrane enzymes? (3)
    • 1- protein tyrosine kinase
    • 2- serine kinase
    • 3- guanylyl cyclase
  9. Activated tyrosine kinases phosphorylate _______ residues on different target signal proteins.
    tyrosine
  10. What type of protein is bound non-covalently to cytokine receptors?
    a tyrosine kinase from the JAK kinase family
  11. What are STATs?
    signal transducers and activators of transcription

    they regulate gene expression
  12. cAMP is degraded to 5'-AMP via what?
    PDE (phosphodiesterases)
  13. _______ _______ are important targets for drug discovery.
    Protein kinases
  14. Specific inhibitors of protein kinases are used in ________ _________
    cancer chemotherapy

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