List three factors which contribute to the emergence of microbial resistance.
- 1) add antibiotics to animal feed (exposing bacterial species to the environment). Quinolones have been traced back to a farm!
- 2) patient non-compliance
- 3) over-use of antibiotics (for example, using them to treat the flu, which is a virus-related infection)
Example of NDM-1: type of co-resistance: encodes for several different antibiotics: spread by R-factors or plasmids. They isolated it in a person who lived in Sweden, but from India. She got sick with a UTI, picked up resistant strain from hospital, went back to Sweden. ND stands for New Delhi.
The more antibiotics you use, the more resistance you breed.