Fungal Infections

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Author:
giddyupp
ID:
64055
Filename:
Fungal Infections
Updated:
2011-02-04 11:49:37
Tags:
Fungal Infections PHPR523 Test2
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Description:
Fungal Infections
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  1. What are the risk factors for developing Candida infections?
    • Colonization
    • Exposure to broad-spectrum antibiotics
    • Central venous catheter
    • Parenteral nutrition
    • CI or cardiac surgery
    • Long hospitalization
    • ICU stay
    • Thermal injury
    • Premature birth
    • Immunosuppression (Neutropenia, HIV, corticosteroids, DM)
  2. What are the 5 most common Candida species that cause human infection?
    • C. albicans:
    • Most common species
    • Susceptible to everything
    • C. glabrata:
    • Low virulence, but difficult to treat
    • Higher mortality
    • Susceptible to AMB and echinocandins
    • Some rst to azoles
    • C. tropicalis :
    • Pronounced involvement of the entire GI tract
    • Susceptible to everything
    • C. parapsilosis:
    • Exogenous infection
    • Susceptible to everything (but a little questionable with echcinocandins)
    • C. krusei:
    • Higher mortality
    • Susceptible to AMB, echinocandins, voriconazole
    • Rst to fluconazole
  3. What is the treatment for Candidemia in a patient who is not severely ill and glabrata or krusei are not suspected?
    • Fluconazole DOC (make sure to use adequate dosing)
    • Echinocandin
    • 14d after last positive blood culture and resolution of symptoms
  4. What is the treatment for Candidemia in a patient who is severely ill or glabrata or krusei is suspected?
    • Use an echinocandin
    • Possibly Fluconazole
    • 14d after last positive blood culture and resolution of symptoms
  5. What is the treatment for invasive Candidiasis in a patient who is not severely ill and glabrata or krusei are not suspected?
    • Fluconazole
    • Echinocandin
    • Treat until all lesions have resolved - months
    • Treat through immunosuppression
  6. What is the treatment for invasive Candidiasis in a patient who is not severely ill and glabrata or krusei is suspected?
    • Echinocandin
    • Possibly Fluconazole
    • Treat until all lesions have resolved - months
    • Treat through immunosuppression
  7. What is the treatment for invasive candidiasis in a patient who is severely ill?
    • LAMB
    • Echinocandin
    • Voriconazole
    • Treat until all lesions have resolved - months
    • Treat through immunosuppression
  8. What are the risk factors for acquiring Aspergillus?
    • Prolonged neutropenia
    • Advanced HIV infection
    • Inherited immunodeficiency
    • Transplant
  9. What is the most common method of acquiring Aspergillus?
    inhalation of conidia
  10. What is the treatment for Aspergillosis?
    • Voriconazole DOC
    • AMB
    • Echinocandins (not monotherapy)
    • Posaconazole
    • Itraconazole
    • Duration of tx: 6-12 wks

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