Antifungal Pharmacology

Card Set Information

Author:
giddyupp
ID:
64069
Filename:
Antifungal Pharmacology
Updated:
2011-02-04 11:50:50
Tags:
Antifungal Pharmacology PHPR523 Test2
Folders:

Description:
Antifungal Pharmacology
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user giddyupp on FreezingBlue Flashcards. What would you like to do?


  1. What is the mechanism of action of the antifungals?
    • Polyene (AMB):
    • Binds to fungal cell membrane and causes leak of electrolytes
    • Azole (fluconazole, itraconazole, posaconazole, voriconazole):
    • Inhibit 14-alpha-demethylase
    • Prevents conversion of lanosterol to ergosterol
    • Echinocandin (anidulafungin, caspofungin, micafungin):
    • Inhibit 1,3-beta-glucan synthase
    • Inhibit glucan synthesis causing osmotic lysis
    • Antimetabolites (flucytosine):
    • Inhibit fungal protein synthesis by replacing uracil with 5-FU in RNA
    • Allylamines (terbinafine):
    • Inhibit ergosterol synthesis through inhibition of squalene epoxidase
  2. What are the main toxicities of the Antifungals?
    • Polyene (AMB):
    • Nephrotoxicity
    • Infusion rxn
    • Azoles:
    • Hepatotoxicity
    • Transient visual disturbances (Voriconazole)
    • Echinocandin (anidulafungin, casp, mica):
    • ↑ LFTs
    • Antimetabolites (flucytosine):
    • Bone marrow suppression
    • NV
    • Allylamines (terbinafine): agranulocytosis
    • GI intolerance
  3. What is the treatment for C. albicans?
    • Static: flucon, itra, posa, vori
    • Cidal: AMB, caspo
  4. What is the treatment for C. glabrata?
    Cidal: AMB, caspo
  5. What is the treatment for C. krusei?
    • Static: itra, posa, vori
    • Cidal: AMB, caspo
  6. What is the treatment for C. tropicalis?
    • Static: flucon, itra, posa, vori
    • Cidal: AMB, caspo
  7. What is the treatment for Cryptococcus?
    • Static: flucon, itra, posa, vori
    • Cidal: AMB (DOC)
  8. What is the treatment for Aspergillus?
    • Static: itra, posa, vori, caspo
    • Cidal: vori (DOC), AMB

What would you like to do?

Home > Flashcards > Print Preview