MED-Promethazine

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Author:
amerelman
ID:
64125
Filename:
MED-Promethazine
Updated:
2011-02-04 15:23:40
Tags:
MED Promethazine
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Description:
MED-Promethazine
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  1. Functional Class
    Anti-emetic, phenothiazine, antihistamine, anti-cholinergic
  2. Mechanism of Action
    Decreases nausea by blocking dopamine and H1 receptors associated with vagal stimulation of the emesis center in the medulla. Also decreases effects of muscarinic receptors in the GI thus decreasing gastric secretions and peristalsis.
  3. Indications
    • N/V
    • Motion sickness
  4. Contraindications
    • Hypersensitivity
    • Less than 2 years old with emesis due to respiratory depression
    • Hypotension
    • Use in with CNS depressants
    • Decreased LOC
  5. Precatautions
    MAOIs, anticholinergics, pregnancy/lactating mothers
  6. Side Effects
    • Sedation
    • Dystonic reaction
    • Tremors
    • Dizziness
    • Blurred vision
    • Diplopia
    • Tinnitus
    • Tissue necrosis if given SC
    • Lowers seizure threshold
  7. Interactions
    MAOIs, antagonizes effects of epinephrine
  8. Dosage and Route
    Adult: 6.25 mg slow IVP or 12.5 mg IM q 4 hours

    Pediatric: 0.25 mg/kg IV/IM
  9. Pharmacokinetics
    • Onset: 5 mins IV, 20 mins IM
    • Duration: 4-6 hours
    • Half-life: 9-16 hours
  10. Note
    May use diphenhydramine for dystonic reactions

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