toxicants must pass thru a number of barriers. (skin, lung, alimentary canal, etc).
- once in blood stream, toxicant is available for distribution.
- Hg, Pb --- CNS, kidney, hemopoietic organs.
- benzene --- hemopoietic organs.
- CCl4 --- liver damage.
- toxicants are eliminated by the body by:
- -biotransformation (liver).
- -excretion (kidney, lungs, biliary).
- -storage (fat).