How does receptor and agonist interaction lead to Up-Regulation?
1. If patient is taking a "blocker" (pharmacologic antagonist)
2. Type of disease/disorder affecting signal transduction pathway
EX: Patients on Beta-blockers, Inc. synthesis of the B-adrenoreceptor in tissue. IF patient STOPS taking, there will be INC. binding of adrenaline to B-adrenoreceptor = MI, tachycardia, death (better to taper off dose, not all of sudden stop)