Antibiotics

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  1. Beta lactam MOA
    Inhibits cell wall synthesis.
  2. Penicillin drugs (3)
    • Penicillin VK - Veetids
    • Amoxicillin - Amoxil
    • Amoxicillin/clavulanate - Augmentin
  3. Penicillin Indications
    AOM, ABS, UTI, pharyngitis
  4. Cephalosporins (3)
    • Cephalexin - Keflex
    • Cefuroxime - Ceftin
    • Cefdinir - Omnicef
  5. Cephalosporins indications
    cellulitis, ABS, AOM, gonorrhea
  6. Beta-lactam counseling points
    • Side effects: N/V/D
    • Allergies: Rash vs anaphylaxis
  7. Sulfonamides MOA
    Inhibits folate synthesis
  8. Sulfonamides drugs (2)
    • Sulfamethoxazole - Bactrim
    • Trimethoprim - Sulfatrim
  9. Sulfonamide indications
    UTI, AOM, PCP
  10. Sulfonamide counseling points
    • Side effects: N/V/D, stevens-johnson syndrome
    • Not for use in pregnant women
    • CYP450 inhibitor
  11. Macrolide MOA
    Binds ribosome and inhibits protein synth
  12. Macrolide drugs (3)
    • Azithromycin - Zpak
    • Erythromycin - Ery-Tab
    • Clarithromycin - Biaxin
  13. Macrolide indications
    CAP, U/LRI, chlamydia
  14. Macrolide counseling points
    • Azithromycin - avoid antacids
    • Erythro/Clarithro - avoid grapefruit
    • Side effects: N/V/D
    • CYP450 inhibitor
  15. Fluoroquinolone MOA
    Inhibits DNA replication/transcription
  16. Fluoroquinolone drugs (3)
    • Ciprofloxacin - Cipro
    • Levofloxacin - Levaquin
    • Moxifloxacin - Avelox
  17. Fluoroquinolone indications
    • UTI, CAP, ABS
    • Cipro - anthrax
  18. Fluoroquinolone counseling points
    • No antacids/dairy
    • Side effects: N/V/D, increased blood sugar in DM
    • Rare - tendon toxicity
    • DI: warfarin/caffeine
  19. Tetracycline MOA
    Binds ribosome and inhibits protein synth
  20. Tetracyclines drugs (3)
    • Tetracycline - Sumycin
    • Doxycycline - Vibramycin
    • Minocycline - Minocin
  21. Tetracycline indications
    Acne, skin infections, STDs
  22. Tetracycline special administration
    • Take with full glass of water and sit up for 30 mins.
    • Avoid antacids/dairy
    • Never take expired medication
  23. Tetracycline counseling points
    • Side effects: N/V/D, indegestion
    • Not for use in pregnant women or children
    • DI: warfarin
  24. Lincosamide MOA
    Binds ribosome and inhibits protein biosynth
  25. Lincosamide drug (1)
    Clindamycin - cleocin
  26. Lincosamide indications
    Upper GI, bacterial vaginosis, topical for acne
  27. Lincosamide counseling points
    • Side effects: N/V/D
    • Black box warning for C. difficile associated diarrhea and Pseudomembranous colitis.
  28. Nitroimidazole MOA
    Destroys DNA structure
  29. Nitroimidazole drug (1)
    Metronidazole - flagyl
  30. Nitroimidazole indications
    C. difficle associated diarrhea, bacterial vanginosis, upper GI
  31. Nitroimidazole counseling points
    • No alcohol!
    • Side effects: dysuria, discolored urine
    • Not for use in pregnant women
  32. Nitrofurantoin MOA
    Inhibit acetyl CoA
  33. Nitrofurantoin drug (1)
    Nitrofurantoin - macrobid
  34. Nitrofurantoin indications
    UTI
  35. Nitrofurantoin counseling points
    • Side effects: N/V/D, discolored urine
    • Not for use in renal impairment cases
    • No magnesium salts

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Author:
kerzikhan
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64357
Filename:
Antibiotics
Updated:
2011-02-06 00:46:19
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