If we were to take these internally and depending on the dose, we need to know if we'll get a beneficial effect of killing the bacteria or an AE of harming the patient (we need to get a balanced effect to avoid harming the patient). We can always increase the [ ] of the Ax to a zone of inhibition when we are in the lab so when we test for Ax, it was always be bacteriocidal (because we are in the lab and we can always kill bacteria). The question is, can we achieve these [ ]'s in a human without harming the patient or causing AE's? If it's bacteriocidal in the lab, is it also in you patient? Sometimes drugs may be bacteriocidal in a lab but -static in a patient.
- ie. Tetracycline = cannot double this dose, we would have to increase by a 20-30 fold and this would harm the patient
- ie. Gentamycin = both static and cidal