Pharm II (mood disorders)1c

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Anonymous
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64458
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Pharm II (mood disorders)1c
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2011-02-06 13:38:41
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Pharm II mood disorders 1c
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Pharm II (mood disorders)1c
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  1. What are the treatment options for Acute Bipolar depression?
    • -Bupropion
    • -SSRI
    • -Tricyclics
    • -Lamotrigine
    • -Quetiapine
    • -Fluoxetine+Olanzapine
  2. What are some treatment options for Acute Mania?
    • Lithium
    • Valproic acid
    • Carbamazepine
    • Antipsychotic drugs
  3. Prophylaxis for Depression and Mania?
    • lamotrigine
    • lithium
    • valproic acid
    • carbamazepine
    • Atypical antipsychotic drugs
  4. What are Lithiums Adverse side effects?
    • GI irritation
    • Tremor
    • Metallic taste
    • Cognitive dulling
    • Weight gain
    • Acne
    • Polydipsia
    • Polyuria
    • Nephrogenic diabetes insipidus can occur
    • Other CNS effects
    • Hypothyroidism
    • Monitor for 6 months
  5. What are symptoms of lithium toxicity?
    experienced at levels 1.5mEq/l and higher

    • Nausia and vomiting
    • CNS effects (Delirium and Coma)
  6. Carbemazepine adverse effects
    • Rash (potentially serious Steven Johnsons syndrome)
    • May have reduction of Granulocytes (need to monitor the WBC levels)
  7. Carbamazepine Metabolism
    Induces its own metabolism (CYP3A4)

    • It reduces the levels of other drugs, such as:
    • -Oral contraceptives
    • -bupropion
    • -alprazolam
    • -nefazodone
    • -Tricyclics
  8. Lamotrigine
    What is it indicated in?
    • Bipolar I disorder
    • (it is more effective in treating the depressive mood episodes than the manic)

    - It blocks dependent Na channels--> inhibits Glutamate release.
  9. What is the effects of Enzyme inducing AEDs such as carbamazepine and phenobarbital added to lamotrigine?

    What are the effects of valproate added to lamotrigine??
    They decrease LTG concentrations ny 40%

    Increases LTG concentrations 2X
  10. Lamotrigine adverse effects?
    • Serious rashes:
    • SJS
    • TEN (toxic epidermanl necrolysis)
    • N/V/D
  11. Drugs for Acute mania and prophylaxis?
    • lithium
    • valproic acid
    • carbamazepine
    • Antipsychotic drugs
    • lamotrigine (prophylaxis ONLY)
  12. Drugs for Acute depression?
    • Antidepressants
    • -bupropion (less switching)
    • -SSRI
    • -fluoxetine long half-life
    • -Tricyclics

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