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Ability of an Ag to bind with immune components
Ability of an Ag to illicit an immune response
Properties of a good immunogen (4)
Larger than 1kDa
Too small to be immunogenic in vivo
Ex. of two good Immunogens based on complexity:
Proteins + Glycoproteins
Lipids + Nucleic Acids (sometimes)
Small part of immunogenic molecule that binds to Ab or TLR
When an Ab recognizes/reacts to a similar epitope
Ex of Cross Reactivity (3):
Brucella abortus & Y. enterocolitica
Acquired Immune Sys is activated by...
Capture, processing and presentation by APCs
(antigen presenting cells)
T-Cells are activated by:
MHC presentation to the TCR
T Cytotoxic cells are activated by...
T Helper cells are activated by...
B-Cells are activated by:
BCRs recognize and bind Ag (w/o special presentation), but still requires T-h to procudes Ab
Cells that present exogenous Ag via MCH II:
Only ____ can present to naieve T cells
After caputring Ag _____ dendritic Cells migrate to lymphoid tissue
_____ dendritic cells process and present Ag in lymph nodes
Exogenous APCs can present endogenous APCs via MCH I when?
When intracellularly infected