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Ability of an Ag to bind with immune components
Ability of an Ag to illicit an immune response
Properties of a good immunogen (4)
- Larger than 1kDa
- Relatively Stable
Too small to be immunogenic in vivo
Ex. of two good Immunogens based on complexity:
- Proteins + Glycoproteins
- Lipids + Nucleic Acids (sometimes)
Small part of immunogenic molecule that binds to Ab or TLR
When an Ab recognizes/reacts to a similar epitope
Ex of Cross Reactivity (3):
- Blood Types
- Brucella abortus & Y. enterocolitica
- Multiple Sclerosis
Acquired Immune Sys is activated by...
- Capture, processing and presentation by APCs
- (antigen presenting cells)
T-Cells are activated by:
MHC presentation to the TCR
T Cytotoxic cells are activated by...
T Helper cells are activated by...
B-Cells are activated by:
BCRs recognize and bind Ag (w/o special presentation), but still requires T-h to procudes Ab
Cells that present exogenous Ag via MCH II:
Only ____ can present to naieve T cells
After caputring Ag _____ dendritic Cells migrate to lymphoid tissue
_____ dendritic cells process and present Ag in lymph nodes
Exogenous APCs can present endogenous APCs via MCH I when?
When intracellularly infected
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