Bact: Antibacterial Drugs I

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HLW
ID:
65126
Filename:
Bact: Antibacterial Drugs I
Updated:
2011-02-09 16:44:11
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Bact
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Bact: Antibacterial Drugs
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  1. Bactericidal-
    Kills bacteria
  2. Bacteriostatic-
    Inhibits growth
  3. Drug groups are based on (2):
    • Mechanism of action
    • Chemical Grouping
  4. Ex. of Bactericidal drug (1):
    Pen
  5. Ex. of Bacteriostatic drug (1):
    Tetracyclines
  6. Aim of antibacterial drugs:
    Maintain effective concentration at infection site
  7. To be an effective dosage, what is required?
    • 3-5x MIC at the site of infection
    • (MIC= Min. Inhibitory Concentration)
  8. Drug Choice is based on (5):
    • Dx
    • Susceptibility of agent
    • Nature of infection (local, systemic)
    • Pharmacokinetics (freq. based on elimination)
    • Host (spp, age, pregnancy)
  9. Strangles is caused by ____ and can be treated w/ ____
    • Streptococcus equi
    • Pen
  10. What drugs should be avoided in bunnies?
    • Pen
    • Ceph
  11. Ex of drug destroyed in stomach:
    Pen G
  12. Ex. of drug not absorbed in GI tract:
    • Aminoglycosides
    • (Gentamicin)
  13. Pink Eye in cattle is cause by ____ and can be Tx w/ ___ or ____
    • Moraxella Bovis
    • Liquamycin LA or Oxytetracycline LA
  14. Mech of action of antibacterial drugs (4):
    • Inhib of wall synthesis
    • Damage to cell membrane function
    • Inhib of Nucleic Acid Synthesis/Function
    • Inhib of protein synthesis
  15. Drugs that inhibit synthesis of wall (2):
    • Pen
    • Ceph
  16. Drugs that damage cell membrane function (1):
    Polymyxins
  17. Drugs that inhib Nucleic Acid Synthesis/Function (3):
    • Sulfonamides
    • Quinolones
    • Enrofloxacin
  18. Drugs that inhib protein synthesis (2):
    • Tetracyclines
    • Aminogylcosides
  19. Mechanisms employed by bacteria to resist drugs (4):
    • Enzymes that destroy/inactivate drug
    • Alteration of target
    • Decreased cell wall perm
    • Alt metabolic pathway
  20. Staph Aureus drug resistance mech:
    B-Lactamase against Pen
  21. B-Lacam drugs (5):
    • Pen G
    • Ampicillin
    • Amoxycillin/Clavamox
    • Cephalosporins
    • Ceftiofur
  22. Potentiated Pen:
    • Amoxi-Calvuneate
    • Amoxi-Sulbactam
    • (counteracts b-lactamase)
  23. 1st Gen B-Lactams (2):
    • Cephalexin
    • Cefadroxil
  24. 3rd Gen B-Lactams (2):
    • Ceftazidime
    • Ceftiofur
    • Aminoglycoside Drugs (1):
    • Gentamicin
  25. Tetracycline Drugs (2)
    • Doxy
    • Oxytetracycline
  26. Macrolide Drugs (4):
    • Erythromycin
    • Tylosin
    • Tiamulin
    • Tilmicosin
  27. Aminoglycosides will kill:
    Pseudomonas
  28. Aminoglycosude Drugs include (5):
    • Streptomycin (Oldest, most resis)
    • Neomycin
    • Kenamycin
    • Gentamycin
    • Amikacin/Tobramycin (Best)
  29. Quinolones...
    Narrow Spectrum (1):
    Broad Spectrum (2)
    • Narrow: Quinolone
    • Broad: Fluoroquinolones
  30. Ex. of quinolone drugs (1):
    Nalidixic Acid
  31. Fluoroquinolone Drugs (3):
    • Cipro
    • Enrofloxacin
    • Orbifloxacin
  32. Fluroquinolones are not effective against...
    Anaerobes
  33. Penn G will Tx (4):
    • Strangles
    • Coryne UTI (cattle)
    • Tetanus
    • Blackleg Prophylaxis
  34. Amp/Amoxi will Tx (1):
    Some Resp. Infections
  35. Amoxi-calvulanate will Tx (4):
    • Pyoderma
    • UTI
    • RI
    • AG Abcess
  36. Ceph/Cefadroxil will Tx (2):
    • Pyoderma
    • UTI
  37. Ceftazidime/Ceftiofur will Tx(2):
    • Wounds
    • RI
  38. Tx Respiratory infections w/ (3):
    • B-Lactams (better)
    • TMS
    • Fluoroquinolones
  39. Tx Pseudomonas wounds w/:
    B-Lactams

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