Pharmacology 7

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Kalanzo
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65156
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Pharmacology 7
Updated:
2011-02-08 23:01:25
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UNLV DPT
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Pharmacology 7
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  1. Depression often involves which NT?
    The amines: Sorotonin, Dopa, Norepi-
  2. What are the main theories of the cuase of depression?
    • Increased sensitivity of postsynaptic amine receptors
    • Increased sensitivity of presynaptic amine recpetors
    • Decreased sensitivity of GC receptors do to stress causing rise in cortisol.
  3. What is the general theory for why antidepressants work?
    The cause a compensatory down-regulation of amine NT and a decreased sensitivity of the pre and post syn amine receptors
  4. Amitriptyline
    • Elavil
    • Tricyclic
    • Blocks reuptake of NT
  5. Nortriptyline
    • Aventyl
    • Tricyclic
    • Blocks reuptake of NT
  6. MOA Inhibitors
    MOA degrades NT, and the MOA inhibitor allows NT to remain in the cleft longer.
  7. MOA Inhibitor type A v. type B
    • Type A: Used for treating depression
    • Type B: Prolongs effects of dopamine
    • Both relatively non selective
  8. SSRI's (3)
    • Fluoxetine (Prozac)
    • Paroxetine (Paxil)
    • Sertraline (Zoloft)
    • Selective for reuptake of Serotonin
  9. SNRI (3)
    • Venlafaxine (Effecor)
    • Mirtazapine (Remeron)
    • Bupropion (Wellbutrin)
    • Selective for Serotonin and Norepi- with out effecting dopamine reuptake
  10. Amitriptyline side effects
    • Elavil
    • Tricyclic, sedation and block ACh recpetors.
    • Confusion, delirium, dry mouth, constipation, urinary retention, tachycardia,arrhythmias, orthostatic, high potential for fatal over dose.
  11. Nortriptyline side effects
    • Aventyl
    • Tricyclic, sedation and block ACh recpetors.Confusion, delirium, dry mouth, constipation, urinary retention, tachycardia,arrhythmias, orthostatic, high potential for fatal over dose.
  12. MOA Inhibitor side effects
    • Hypertensive situation
    • CNS excitation
    • Anticholinergic effects
    • Adverse effects when taken with fermented foods
  13. 2nd Generation side effects
    • Less sedation, but more GI problems
    • Serotonin syndrome: sweating, shivering, movement disorders and muscle fasciculations
  14. Lithium
    • Used to treat bipolar disorders
    • May deecrease excitability by competing with other cations.
    • Not metabolized in body, so risk of toxic levels causing seizures coma or death

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